Zinc oxide nanopartciles (ZnONPs) involved in advanced technologies, and their wide-scale use in consumer market makes human beings more prone to the exposure to ZnONPs. The present study was undertaken to evaluate amelioration of ZnONP-induced toxicities with querectin in male albino rats. ZnONPs-treated rats showed a significant decrease in sperm cell count, sperm motility, live and normal sp...

Organotin compounds are a versatile group of organometallic chemicals that are used in a variety of industrial and agricultural applications. Tributyltin (TBT), a common organotin, brings about severe spermatotoxic and organotoxic effects. However, information about the adverse effects of TBT on liver, kidney and testis is scanty. Hence, the present study was undertaken to elucidate the TBT-med...

Aged testes undergo profound histological and morphological alterations leading to a reduced functionality. Here, we investigated whether variations in longevity affect the development of local inflammatory processes, the oxidative state and the occurrence of apoptotic events in the testis. To this aim, well-established mouse models with delayed (growth hormone releasing hormone-knockout and Am...

background cyclosporine a (csa)-induced hepatotoxicity could be due to a reduction in α2β1 integrin expression that may either be from the direct effect of csa itself or from reactive oxygen species (ros) overproduction. objectives in this study we aimed to identify the cellular mechanisms underlying csa-induced hepatic injury by investigating the activation patterns of the antioxidant enzymes,...

Testis is very rich in unsaturated fatty acids with poor antioxidant defense system and due to presence of a potential reactive oxygen species (ROS)-generating systems, it is much more vulnerable to oxidative damage than other tissues. Thyroid hormones are well known to regu la te s te ro idogenes is and spermatogenesis, thereby, affecting male fertility. In the presence of disturbed thyroid co...

In previous studies, we established that kolaviron (KV) (a biflavonoid from Garcinia kola seeds) elicited anti-oxidative and hepatoprotective effects in Wistar rats chronically treated with ethanol. The present study investigates the possible ameliorative effect of KV against ethanol-induced reproductive toxicity in male Wistar rats. Twenty-eight rats were randomly divided into four groups of s...

background: there are studies that indicated dyshomeostasis of oxidant/antioxidant and trace elements in breast cancer patients, but the data regarding the status of these parameters in various stages of breast cancer are limited. the aim of this study was to highlight the status of these biochemical factors in various stages of breast cancer. methods: fifty-eight breast cancers patients partic...

background: tissue protective effect of compounds with antioxidant properties has been demonstrated. the alkaloids found in barberry root are considered as antioxidants. objective: according to barberry protective effects in different tissues, in this study, the protective effect of berberis integerrima bge. root )mebir) was evaluated against ccl4-induced testicular damages in wistar rats. mate...

This study was done to evaluate the effects of lead nitrate and mercury chloride in testis tissues of Wistar rats. Lead nitrate and mercury chloride are widely used heavy metals in industry. Oral lead and mercury administrations to adult male rats at doses 45 mg/kg bw and 0.02 mg/kg bw, respectively for 4 weeks caused a significant increasing in MDA levels and antioxidant enzyme activities (SOD...

This study investigated the antioxidant system response of male reproductive organs during early and late phases of diabetes and the influence of melatonin treatment. Melatonin was administered to five-week-old Wistar rats throughout the experiment, in drinking water (10 μg/kg b.w). Diabetes was induced at 13 weeks of age by streptozotocin (4.5 mg/100 g b.w., i.p.) and animals were euthanized w...