Semi-synthetic tetracyclines (TCs) have been reported to reduce pathological bone resorption through several mechanisms, although their effect over bone physiological metabolism is not yet fully understood. The present study aims at evaluate the behaviour of osteoblastic-induced human bone marrow cells regarding proliferation and functional activity, in the presence of representative therapeuti...

The tetracyclines are a group of broad-spectrum antibiotics which were discovered in 1948 following the isolation of chlortetracycline from Streptomyces aureofaciens (4). Later, other tetracyclines (Table 1) were identified; they were either naturally occurring molecules (tetracycline, demethylchlortetracycline) or products of semisynthetic approaches (doxycycline, minocycline) (4). The tetracy...

The effect of decomposition and diagenesis of sediment organic matter (SOM) on the adsorption of emerging pollutants by the sediment has been seldom addressed. In the present experimental study, artificial sediment was incubated to simulate the natural organic diagenesis process and hence investigate the influence of organic diagenesis on the adsorption of tetracyclines (TCs) by marine sediment...

A series of monodisperse magnetic nanoparticles (NPs) MFe2O4 (M = Fe , Mn, Co, Zn) was synthesized through an improved sonohydrothermal method and then characterized for their structural properties. NaOH concentration and hydrothermal temperature were examined for their effects on the crystallization of MFe2O4 NPs. Thereafter, the synthesized NPs were applied to remove three commonly-used tetra...

Swine wastewater represents an important pollution source of antibiotics in the environment; however, regional data about residual antibiotics in swine wastewater are very limited at present. This study investigated the concentrations of three classes of commonly used veterinary antibiotics, including five sulfonamides (SAs), three tetracyclines (TCs) and one macrolide (tiamulin, TIA), in swine...

Tetracyclines (TCs) are widely used for prevention and control of infectious diseases and have a great activity against variety of Gram-positive and Gram-negative bacteria. Due to the widespread use of TCs in animal husbandry, it can lead to an increase the risk of TCs remaining in human food. To protect consumers, many countries have set acceptable tolerance levels for these drugs. Therefore, ...

Sexual offender treatment programmes are often facilitated in secure settings such as prisons or psychiatric hospitals, which are not ideal environments for such treatment. Arguably, however, when these environments are structured as therapeutic communities (TCs), opportunities are created to enhance the effectiveness of treatment. This article describes the concept of a TC, its operating princ...

Telocytes (TCs) are interstitial cells with telopodes - very long prolongations that establish intercellular contacts with various types of cells. Telocytes have been found in many organs and various species and have been characterized ultrastructurally, immunophenotypically and electrophysiologically (www.telocytes.com). Telocytes are distributed through organ stroma forming a three-dimensiona...

Land use in east China tends to change from paddy rice to vegetables or other high-value cash crops, resulting in high input rates of organic manures and increased risk of contamination with both heavy metals (HMs) and antibiotics. This investigation was conducted to determine the accumulation, distribution and risks of HMs and tetracyclines (TCs) in surface soils and profiles receiving differe...

Tetracyclines (TCs) are a group of antibiotics comprising of a common tetracycline (TET) nucleus with variable X(1) and X(2) positions on 5 and 6 carbon atoms, such as oxytetracycline (OTC) and doxycycline (DOX). In this study, the tetracycline group specific (TGS) ssDNA aptamers were identified by modified SELEX method by employing tosylactivated magnetic beads (TMB) coated with OTC, TET, and ...