BACKGROUND β-thalassemia is the most common hereditary disease in Iran and more than 2 million carriers of the β-thalassemia mutant gene are living in this country. OBJECTIVE To determine pregnancy outcome of women with β-thalassemia minor. MATERIALS AND METHODS In this retrospective, case-control study in two universities affiliated hospitals in Shiraz, all pregnancies occurred between 200...

  Background :Highserum level of cancer antigen 15.3 (CA15.3) has been reported in some malignant and nonmalignant conditions including thalassemia major which could have been resulted from ineffective erythropoiesis. We aimed to evaluate the serum level of CA15.3 in carriers of beta-thalassemia by comparing them with cancer patients and healthy individuals.   Methods : This cross-sectional stu...

background:   objective: to determine pregnancy outcome of women with β-thalassemia minor.   materials and methods: in this retrospective, case-control study in two universities affiliated hospitals in shiraz, all pregnancies occurred between 2006 and 2008 were included. patients were divided in two groups regarding the presence of β-thalassemia minor. patients in case and control groups were m...

background: thalassemia is the most common monogenic disease in south-east of iran. despite the 70% reduction in iranian thalassemia cases after thalassemia control comprehensive program, 601 affected babies were born in sistan and balouchistan province, iran from 2002 to 2010, so this study aims at investigating the causes of new thalassemia cases. methods: data from this retrospective cross-s...

amelogenesis imperfecta is a group of genetic disorders that affects both the morphology and quality of tooth structure. although the disease entity is primarily associated with abnormalities of dental and oral structures, it has been reported to be associated with a few syndromes. a 9-year-old girl with minor thalassemia referred to the department of pediatric dentistry of the mashhad faculty ...

introduction: in  major b -thalassemia impaired biosynthesis of beta hemoglobin leads to accumulation of unpaired alpha hemoglobin chain. an iron overload generates oxygen-free radicals which ultimately leads to tissue injury. the aim of this investigation was to evaluate serum antioxidants in patients with major b -thalassemia and those with minor thalassemia in comparison with respective age ...

Background: β-thalassemia minor is characterized by reduced β-haemoglobin chain synthesis and sometimes mild anaemia, although carriers of β-thalassemia minorare usually clinically asymptomatic.Nonspecific abdominal complaints may be caused by gastrointestinal carbohydrate malabsorption (lactose and fructose) and/or malabsorption of biogenic amines (histamine), or proteins (gluten). Objectives:...

OBJECTIVES Evaluation of the peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements in children with thalassemia minor. METHODS In this cross-sectional and comparative study, 30 thalassemia minor patients and 36 controls were included. Heidelberg spectral domain optical coherence tomography was used for peripapillary retinal n...

hemoglobinopathies are the most common single gene disorders worldwide with a considerable frequency in certain area particularly mediterranean and middle eastern countries. hemoglobinopathies include structural variants of hemoglobin (hb s, hb c, hbe,…) and thalassaemias which are inherited defects in the globin chains synthesis. the present study was conducted to determine the prevalence of h...