1.1 Simple derivation of GBLUP Models for genomic selection are abundant. However, most of them rely (yet not all; [1] ) in a hierarchical formulation in which SNP markers (or haplotypes) have additive effect on the trait of interest [2]. We will focus here in models including biallelic SNP markers. Thus, n markers will have n effects, a1 ... an. Although markers have 2 alleles, a single effect...

This paper is an academic reflection on the Activity Theoretical Iterative Evaluation Method (ATIEM). ATIEM is based on Activity Theory (AT), and aims to concretise the abstract concepts of AT into a practical method for evaluation that can be applied by IS practitioners without requiring in-depth knowledge of the theory. We describe how the method was developed, its links to AT, and the applic...

Sequential quadratic programming (SQP) methods form a class of highly efficient algorithms for solving nonlinearly constrained optimization problems. Although second derivative information may often be calculated, there is little practical theory that justifies exact-Hessian SQP methods. In particular, the resulting quadratic programming (QP) subproblems are often nonconvex, and thus finding th...

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In 1981, Paris and Wilkie raised the open question about whether and to what extent the axiom system IΣ0 did satisfy the Second Incompleteness Theorem under Semantic Tableaux deduction. Our prior work showed that the semantic tableaux version of the Second Incompleteness Theorem did generalize for the most common definition of IΣ0 appearing in the standard textbooks. However, there was an alter...

The inverse stellar structure problem determines the equation of state of the matter in stars from a knowledge of their macroscopic observables (e.g. their masses and radii). This problem was solved in a previous paper by constructing a spectral representation of the equation of state whose stellar models match a prescribed set of macroscopic observables. This paper improves and extends that wo...