BACKGROUND Melatonin synchronizes central but also peripheral oscillators (fetal adrenal gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of biological functions through circadian rhythms (24-hour cycles) in relation to periodic environmental changes and therefore adaptation of the individual to his/her internal and external environment. Measures of m...

Stroke represents one of the major causes of death and disability worldwide, for which no effective treatments are available. The thrombolytic drug alteplase (tissue plasminogen activator or tPA) is the only treatment for acute ischemic stroke but its use is limited by several factors including short therapeutic window, selective efficacy, and subsequent haemorrhagic complications. Numerous pre...

Clinical research regarding the therapeutic benefits of cannabis ("marijuana") has been almost non-existent in the United States since cannabis was given Schedule I status in the Controlled Substances Act of 1970. In order to discover the benefits and adverse effects perceived by medical cannabis patients, especially with regards to chronic pain, we hand-delivered surveys to one hundred consecu...

Natriuretic peptides play an important role in water and salt homeostasis and in the regulation of the cardiovascular system. In recent years, exogenous administration of natriuretic peptides has primarily been used to improve our understanding of the role of natriuretic peptides. Also, it became evident that natriuretic peptides may be used therapeutically. Because of their peptide character, ...

to physicians, meat is considered as the best nutrition because it includes rich protein that is necessary for the construction of body cells and tissues. also meat is regarded as the basic food meeting the nutritional and therapeutic needs of human beings. meat, because of containing the high nutritional value, has been a good indicator of economic growth and social welfare of communities. var...

We are experiencing a worldwide epidemic of obesity and type II diabetes. Our group has been interested in the development of both white and brown fat, particularly at the level of gene transcription. PGC1a was first described as a coactivator of PPARg in the control of brown fatmediated thermogenesis. More recent work has shown that PGC1a controls much of an exercise program in skeletal muscle...

Currently there are only three FDA-approved drugs available for the treatment of metastatic melanoma: dacarbazine, interleukin-2, and the lesser-used hydroxyurea. None of these drugs has been shown to improve overall survival (OS). The review by Thumar and Kluger provides a well-balanced overview of ipilimumab, the first agent to demonstrate a survival benefit in patients with metastatic melano...

Centella asiatica belongs to family Apiaceae is a traditionally important plant with wide range of therapeutic potential. Plant is traditionally used to treat a broad range of diseases such as diarrhea, hepatitis, measles, toothache, syphilis, leucorrhoea etc. Madecassic acid, asiatic acid, α-terpinene, α-copaene, β-caryophyllene are some of the important bioactive compounds responsible for its...

To evaluate the sensitivity and specificity of Community Health Survey (CHS), we analyzed data from 11,217 participants aged ≥ 19 yr, in 13 cities and counties in 2008. Three healthcare utilization indices (admission, outpatient visits, dental visits) as comparative variables and the insurance benefit claim data of the Health Insurance Review & Assessment Service as the gold-standard were used....