The burden of human disease related to medically important fungal pathogens is substantial. An improved understanding of antifungal pharmacology and antifungal pharmacokinetics-pharmacodynamics has resulted in therapeutic drug monitoring (TDM) becoming a valuable adjunct to the routine administration of some antifungal agents. TDM may increase the probability of a successful outcome, prevent dr...

Therapeutic drug monitoring (TDM) aims to offer assistance clinicians improve dosing and clinical outcomes, while minimizing the probability of serious adverse effects in routine clinica...

Therapeutic drug monitoring (TDM) can improve clinical care when using drugs with pharmacokinetic variability and a narrow therapeutic window. Rapid, reliable, easy-to-use detection methods are required in order to decrease the time of analysis also enable TDM resource-limited settings or even at bedside. Monitoring methotrexate (MTX), an anticancer drug, is critical since it needed follow clea...

In the last 20 years, several prospective studies have been conducted to improve the expediencyof Therapeutic Drug Monitoring(TDM) application in the field of oncology. However, to start and maintain modern TDM services in developing countries requires more funding and education to reform clinical practices.In the present study, we aimed to determine the current practice of chemotherapy and non...

Antifungal agents may be associated with significant toxicity or drug interactions leading to sub-therapeutic antifungal drug concentrations and poorer clinical outcomes for patients with haematological malignancy. These risks may be minimised by clinical assessment, laboratory monitoring, avoidance of particular drug combinations and dose modification. Specific measures, such as the optimal ti...

Abstract Background Therapeutic drug monitor (TDM) guided optimized dosing of Voriconazole allows optimal exposure in the management mold infection (MI). In addition to already known nuances pharmacokinetics such as CYP2C19 genetic polymorphism and role interactions both necessitating TDM, case reports have suggested that auto-induction may occur after initially achieving a therapeutic level. W...

Invasive fungal infections cause significant morbidity and mortality in patients with concomitant underlying immunosuppressive diseases. The recent addition of new triazoles to the antifungal armamentarium has allowed for extended-spectrum activity and flexibility of administration. Over the years, clinical use has raised concerns about the degree of drug exposure following standard approved dr...

Therapeutic drug monitoring (TDM), i. e., the quantification of serum or plasma concentrations of medications for dose optimization, has proven a valuable tool for the patient-matched psychopharmacotherapy. Uncertain drug adherence, suboptimal tolerability, non-response at therapeutic doses, or pharmacokinetic drug-drug interactions are typical situations when measurement of medication concentr...

The use of therapeutic drug monitoring (TDM) in the treatment of HIV-infection is gaining momentum in resource-rich countries. However, data justifying its use is still in short supply. In this manuscript we review the necessary components of TDM before it should be implemented in widespread clinical use. In addition, we provide specific examples of clinical situations where TDM is likely to us...