The mortality of burn patients remains high in spite of the advances made in treating initial burn shock, controlling burn wound infection, and providing nutritional support. Smoke inhalation is recognized as a strong determinant of morbidity and mortality in burn patients, and most burn patients die because of associated inhalation injury. There are many reports on this combined injury (cutane...

Various studies have shown that alcohol exposure before thermal injury leads to increased morbidity and mortality. Pulmonary failure is a major complication seen in these patients. This study examines the effects of prior alcohol exposure on lung pathology after burn injury. There is a marked increase in neutrophil recruitment in the lung after thermal injury, and herein we show that this appea...

We evaluated the dependency of neutrophil O production on PTK-Lyn and MAPK-ERK1/2 in rats after thermal injury. Activation of PTK-Lyn was assessed by immunoprecipitation. Phosphorylation of ERK1/2 was assessed by Western blot analysis. O production was measured by isoluminol-enhanced luminometry. Imaging technique was employed to measure neutrophil [Ca2+](i) in individual cells. Thermal injury ...

Severe burn injury can result in dramatic changes in human physiology and biochemistry. Aberrant responses, hypersensitivity and potentially lethal hyperkalemia to depolarising [1,2] and hyposensitivity to non-depolarising [2,3] muscle relaxants have been noted in burn trauma. The molecular basis of these responses is currently thought to be due to an increase in nicotinic acetylcholine recepto...

An assessment of burn depth is a key step in guiding the treatment of patients who have sustained thermal injuries. Polarization-sensitive optical coherence tomography (PS-OCT) might eventually provide the physician with a quantitative estimate of actual burn depth. Burns of various depths were induced by contacting rat skin with a brass rod preheated to 75 degrees C for 5, 15, or 30 s. Thermal...

BACKGROUND Abnormal acute pain after burn injury still torments patients severely. In this study, we investigated that one voltage gated sodium channel Nav1.7 plays a vital role in lowering heat pain threshold after burn injury, and the hypothesis that knockdown of Nav1.7 attenuates pain following burn injury. METHODS Sixty eight adult male Sprague-Dawley rats were divided into 4 treatment gr...

Fazal, Nadeem, Walid M. Al-Ghoul, Megan J. Schmidt, Mashkoor A. Choudhry, and Mohammed M. Sayeed. Lynand ERK-mediated vs. Ca2 -mediated neutrophil O2 responses with thermal injury. Am J Physiol Cell Physiol 283: C1469–C1479, 2002. First published June 20, 2002; 10.1152/ajpcell.00114.2002.—We evaluated the dependency of neutrophil O2 production on PTK-Lyn and MAPKERK1/2 in rats after thermal inj...

Burn-in faces significant challenges in recent CMOS technologies. The self-generated heat of each IC in a burn-in environment contributes to larger currents that can lead to further increase in junction temperatures, possible thermal run away, and yield-loss of good parts. Calculations show that the junction temperature is increasing by 1.45X/generation. This paper estimates the increase in jun...

S ince 1952, the US Army Institute of Surgical Research (USAISR) Burn Center has provided comprehensive care for patients who have sustained severe thermal trauma, inhalation injury, and other diseases related to burn trauma. The Army Burn Center serves the entire population encompassed by the military health care system as well as veterans and civilian emergency patients requiring burn center ...