OBJECTIVE The objective of this study was to compare treatment persistence and rates of seizure-related events in patients who initiate antiepileptic drug (AED) therapy with a generic versus a brand-name product. METHODS We used linked electronic medical and pharmacy claims data to identify Medicare beneficiaries who initiated one of five AEDs (clonazepam, gabapentin, oxcarbazepine, phenytoin...

OBJECTIVE While tocilizumab (TCZ) is known to increase low-density lipoprotein (LDL) cholesterol levels, it is unclear whether TCZ increases cardiovascular risk in patients with rheumatoid arthritis (RA). This study was undertaken to compare the cardiovascular risk associated with receiving TCZ versus tumor necrosis factor inhibitors (TNFi). METHODS To examine comparative cardiovascular safet...

OBJECTIVE Data on early risk of infection in patients receiving their first treatment for type 2 diabetes are limited. We examined rates of community-based antibiotic use and hospital-treated infection in initiators of metformin and other glucose-lowering drugs (GLDs). DESIGN Population-based cohort study using medical databases. SETTING General practice and hospitals in Denmark. PARTICIP...

ε-caprolactone (CL) has been enzymatically polymerized using α-amino acids based on sulfur (methionine and cysteine) as (co-)initiators and immobilized lipase B of Candida antarctica (CALB) as biocatalyst. In-depth characterizations allowed determining the corresponding involved mechanisms and the polymers thermal properties. Two synthetic strategies were tested, a first one with direct polymer...

Electrospun polyelectrolyte hydrogel nanofibres are being developed for many applications including artificial muscles, scaffolds for tissue engineering, wound dressings and controlled drug release. For electrospun polyelectrolytes, a post-spinning crosslinking process is necessary for producing a hydrogel. Typically, radiation or thermal crosslinking routines are employed that require multifun...

OBJECTIVE To examine the risk of colorectal cancer after orlistat initiation in the UK population. DESIGN Retrospective matched cohort study. SETTING Data from the UK Clinical Practice Research Datalink from September 1998 to December 2008. PARTICIPANTS 33,625 adults aged 18 years or over who started treatment with orlistat; each orlistat initiator was matched to up to five non-initiators...

OBJECTIVES To compare 1-year direct healthcare costs and utilization among children and adolescents initiating non-stimulant medications atomoxetine (ATX) or extended-release guanfacine (GXR). METHODS In this retrospective, observational cohort study, children and adolescents aged 6-17 years with attention deficit/hyperactivity disorder (ADHD) who had ≥1 prescription claim for ATX or GXR betw...

A series of Type I photoinitiators (PIs) based on a nitrocarbazole scaffold are developed and examined for the first time as visible light photopolymerization. Three oxime esters (OXE-M, OXE-V, OXE-P) varying by terminal groups (acetyl, acryloyl benzoyl) attached via ester group originally prepared. As result this, three PIs exhibit excellent photoinitiation abilities in presence acrylate monom...