The extensive pharmacological applications of the pyrazole-based compounds stimulated us to synthesize highly functionalized, pyrazolylmalonyl diisothiocyanate derivative (2) via treating 2-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)malonyl dichloride (1) with ammonium thiocyanate in acetonitrile at room temperature. 2 was subsequently conducted a double molar ratio different nitrogen nucleophile...

A new method for the determination of cobalt was developed by dispersive liquid-liquid microextraction preconcentration and flame atomic absorption spectrometry. In the proposed approach, 1,5-bis(di-2-pyridyl) methylene thiocarbohydrazide (DPTH) was used as a chelating agent, and chloroform and ethanol were selected as extraction and dispersive solvents. Some factors influencing the extraction ...

In this work, we reported the synthesis and evaluation of antimycobacterial and antifungal activity of a series of thiocarbohydrazone derivatives which are thiacetazone congeners. The target compounds were synthesized in superior yields by reacting thiocarbohydrazide with different aromatic aldehydes and methyl ketones. Compounds 8, 19 and 25 were found to be the most potent derivatives, exhibi...

A series of cyclic analogues of bioactive thiosemicarbazide derivatives have been synthesized as potential antimycobacterial agents. The 4-amino-1,2,4-triazole-5-thione analogues (Ia-f) were prepared by heating a mixture of thiocarbohydrzide and appropriate carboxylic acids. Reaction of thiocarbohydrazide with γ-ketoesters in the presence of sodium methoxide furnished triazolopyridazine derivat...

A method is proposed for the solvent extraction of cadmium using 1,5-bis(di-2-pyridylmethylene)thiocarbohydrazide (DPTH) as extractant. The optimum extraction conditions were evaluated from a critical study of the effect of pH, concentration of extractant, shaking time and ionic strength. The maximum volume ratio of the aqueous to organic phase was 30:1 for a single-stage extraction of99-100% o...

This mini-review covers chelating sorbents anchored to silica gel and their analytical applications for the preconcentration, separation and determination of trace metal ions, focussing mainly on the last 20 years. The article summarizes also the experience gathered by our research group in the synthesis and characterization of new modified silica gels "via silanization", and their affinity tow...