Phenols and aryl thiols are fundamental building blocks in organic synthesis and final products with interesting biological activities. Over the past decades, substantial progress has been made in transition-metal-catalyzed coupling reactions, which resulted in the emergence of new methods for the synthesis of phenols and aryl thiols. Aryl halides have been extensively studied as substrates for...

Changes in concentration of reduced and oxidized low-M(r) thiols were measured in blood and plasma before and after the separation of blood cells. If centrifugation of blood was postponed, the reduced form of homocysteine in plasma increased with time at 22 degrees C; in contrast, the concentrations of other reduced thiols (cysteine, glutathione, and cysteinylglycine) decreased. In plasma the r...

Polysulfides typically react readily with thiols, thus, reactions of endogenous cellular thiols with the polysulfide linkage in naturally-occuring pentathiepin cytotoxins are likely to be an important aspect of their biological chemistry. Here, it is reported that the reaction of thiols with the pentathiepin ring system initially produces a complex mixture of polysulfides that further decompose...

Cellular thiol pools have been shown to be important in the regulation of the redox status of cells, providing a large antioxidant pool consisting of free thiols, thiols bound in the disulfide form and thiols bound to proteins. However, experimental studies with the thiol cysteamine and its disulfide cystamine have demonstrated dramatic cytoprotection in experimental models where antioxidants p...

Thiyl radicals are formed from one-electron oxidation of thiols. Thiyl radicals participate in a number of reactions including electron transfer, hydrogen abstraction and addition reactions with several biological constituents and xenobiotics. Thiyl radicals can be detected by optical spectroscopy or by electron spin resonance (ESR) spectroscopy. Thiyl radicals appear to play a role in the nitr...

BACKGROUND There has been much interest in targeting intracellular redox pathways as a therapeutic approach for cancer. Given recent data to suggest that the redox status of extracellular protein thiol groups (i.e. exofacial thiols) effects cell behavior, we hypothesized that redox active anti-cancer agents would modulate exofacial protein thiols. METHODOLOGY/PRINCIPAL FINDINGS To test this h...

Alkaline sunflower protein extraction can be performed along with de-phenolization of seed proteins if greening is unwanted. This promoted at alkaline pH when chlorogenic acid (CGA) oxidizes and reacts amino acids such as lysine. Thiol-containing dough conditioners: L-cysteine hydrochloride glutathione (GSH) were investigated an alternative de-greening strategy to acidification de-phenolization...

Mixed-addenda vanadium substituted polyoxometalate supported on anatase TiO2 crushed nano leaf was synthesized by an unusual reaction with titanium tetraisopropoxide at 100 ºC via sol–gel method under oil-bath condition. The materials characterized by XRD, TEM,  IR and UV–vis  techniques.  In  the  present  work,  efficient  oxidative  of  thiols  with  polyoxometalate-TiO2/hydrogen  peroxide  ...

The removal of bound metal ions from G-actin uncovered two thiols, Cys-10 and Cys-257. The uncovering of these thiols requires a free calcium concentration lower than 10 nM. Therefore, participation of one or both thiols in Ca2+ binding is suggested. Actin labeled with N-(5-fluoresceinyl)maleimide in the absence of calcium moves as a doublet in NaDodSO4/PAGE. It is suggested that two conformers...

The administration of thiol-containing drugs decreases taste acuity in man and animals. Copper (II) and zine (II) administration returns taste acuity to normal levels. The results suggest that (1) thiols and metals are in dynamic equilibrium in the metabolic net, (2) regulation of taste acuity occurs through changes which thiols and/or metals bring about in the conformation of a protein which l...