BACKGROUND Thyroid hormone plays a critical role in fetal development. In pregnancy, increased thyroid hormone synthesis is required to meet fetal needs, resulting in increased iodine requirements. OBJECTIVE This article outlines changes to thyroid physiology and iodine requirements in pregnancy, pregnancy specific reference ranges for thyroid function tests and detection and management of th...

OBJECTIVE The aim of this study was to elucidate the effectiveness of lithium carbonate prior to thyroidectomy or radioiodide therapy in patients with thyrotoxicosis. SUBJECTS AND METHODS Lithium carbonate was used as preoperative preparation or radioiodide therapy in 5 patients with Graves' disease and in 1 patient with toxic multinodular goiter because of side effects of thionamide in 5 pat...

Sir, Amiodarone-induced thyrotoxicosis is well known for being difficult to treat. Thionamide drugs often fail,' and if possible amiodarone should be stopped. Recently there has been much work and discussion on the use of thionamides combined with potassium perchlorate, and the use of corticosteroids in the treatment of this condition. A 49 year old man presented to clinic having lost 2 stones ...

This study provides for the first time clear evidence that block and replace (BR) strategy (combination of carbimazole plus levothyroxine) is not superior to dose titration (DT) treatment paediatric Graves’ disease.