نتایج جستجو برای: thioredoxin h

تعداد نتایج: 536443  

Journal: :The Journal of biological chemistry 1989
I Slaby A Holmgren

Phage T7 DNA polymerase contains Escherichia coli thioredoxin as a subunit and is a 1:1 complex with T7 gene 5 protein. The enzyme showed high thioredoxin activity in assays at 37 degrees C using reduction of insulin disulfides with NADPH and thioredoxin reductase, leading Randahl (Randahl, H. (1982) FEBS Lett. 150, 109-113) to propose that the thioredoxin dithiol active site is exposed in T7 D...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1998
N Mouaheb D Thomas L Verdoucq P Monfort Y Meyer

Whereas vertebrates possess only two thioredoxin genes, higher plants present a much greater diversity of thioredoxins. For example, Arabidopsis thaliana has five cytoplasmic thioredoxins (type h) and at least as many chloroplastic thioredoxins. The abundance of plant thioredoxins leads to the question whether the various plant thioredoxins play a similar role or have specific functions. Becaus...

Journal: :Hypertension 2009
Shaoping Xu Ying He Martina Vokurkova Rhian M Touyz

In intact vessels, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) act as an integrated system, possibly through reactive oxygen species (ROS). Using a coculture system we tested whether ECs modulate VSMC redox status by regulating activity of NAD(P)H oxidase and antioxidants. VSMC production of O(2)(*-), H(2)O(2), and NO was assessed using fluoroprobes and amplex-red. NAD(P)H ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
H Yano J H Wong Y M Lee M J Cho B B Buchanan

Thioredoxins are 12-kDa proteins functional in the regulation of cellular processes throughout the animal, plant, and microbial kingdoms. Growing evidence with seeds suggests that an h-type of thioredoxin, reduced by NADPH via NADP-thioredoxin reductase, reduces disulfide bonds of target proteins and thereby acts as a wakeup call in germination. A better understanding of the role of thioredoxin...

2013
Yoko Nakatsukasa Hirokazu Tsukahara Kazuhisa Tabuchi Masako Tabuchi Tomoko Magami Mutsuko Yamada Yosuke Fujii Masato Yashiro Mitsuru Tsuge Tsuneo Morishima

This study examined the clinical and biological importance of thioredoxin-1, a redox-active defensive protein that controls multiple biological functions, in pregnant women. We measured serum concentrations of thioredoxin-1, total hydroperoxides, and redox potential in 60 pregnant women at the early third trimester: gestational age of 27-29 weeks. The thioredoxin-1 concentration (mean ± SD) was...

2009
Shaoping Xu Ying He Martina Vokurkova Rhian M. Touyz

In intact vessels, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) act as an integrated system, possibly through reactive oxygen species (ROS). Using a coculture system we tested whether ECs modulate VSMC redox status by regulating activity of NAD(P)H oxidase and antioxidants. VSMC production of O2 ● , H2O2, and NO was assessed using fluoroprobes and amplex-red. NAD(P)H oxidase...

Journal: :iranian biomedical journal 0
مهدی حبیبی انبوهی mahdi habibi anbouhi آیدا فیض برازنده aida feiz barazandeh سعید بوذری saeid bouzari محسن ابوالحسنی mohsen abolhassani حسین خان احمد hossein khanahmad مجید گلکار majid golkar محمدرضا آقاصادقی

background: targeting of cd20 antigen with monoclonal antibodies has become the mainstay in the treatment of non-hodgkin's lymphomas and immunotherapeutic depletion of malignant b cells. accessibility of antigen is one of the crucial factors in development of monoclonal antibodies against this antigen. one major problem in expression of full length cd20 is aggregation and misfolding. there...

Journal: :The Journal of biological chemistry 2000
C Bréheĺin N Mouaheb L Verdoucq J M Lancelin Y Meyer

The disruption of the two thioredoxin genes in Saccharomyces cerevisiae leads to a complex phenotype, including the inability to use methionine sulfoxide as sulfur source, modified cell cycle parameters, reduced H(2)O(2) tolerance, and inability to use sulfate as sulfur source. Expression of one of the multiple Arabidopsis thaliana thioredoxins h in this mutant complements only some aspects of ...

Journal: :Plant physiology and biochemistry : PPB 2004
Eric Gelhaye Nicolas Rouhier Jean-Pierre Jacquot

In plants, thioredoxins h are encoded by a multigenic family of genes (eight in Arabidopsis thaliana, at least five in Populus sp.). The multiplicity of these isoforms raises the question of their specificity. This review focuses on thioredoxins h in two plant models: Arabidopsis and poplar. Thioredoxins h can be divided into three different subgroups according to the analysis of their primary ...

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