Two side effects which limit the use of cisplatin in cancer chemotherapy are severe nephrotoxicity and ototoxicity. The concurrent administration of sodium thiosulfate with cisplatin reportedly protects from cisplatin nephrotoxicity, however, protection from ototoxicity has not been documented. The purpose of this study was to examine the efficacy of using thiosulfate to ameliorate the ototoxic...

BACKGROUND Hydrogen sulfide (H2S) exhibits protective effects in various disease models including cerebral ischemia-reperfusion (I/R) injury. Nonetheless, mechanisms and identity of molecules responsible for neuroprotective effects of H2S remain incompletely defined. In the current study, we observed that thiosulfate, an oxidation product of H2S, mediates protective effects of an H2S donor comp...

Aleem, M. I. H. (Research Institute for Advanced Studies, Baltimore, Md.). Thiosulfate oxidation and electron transport in Thiobacillus novellus. J. Bacteriol. 90:95-101. 1965.-A cell-free soluble enzyme system capable of oxidizing thiosulfate was obtained from Thiobacillus novellus adapted to grow autotrophically. The enzyme systems of autotrophically grown cells brought about the transfer of ...

Inorganic thiosulfate has been implicated as an intermediate in the assimilation of sulfate in a variety of organisms. Nutritional studies with mutants of Aspergillus have been interpreted to indicate thiosulfate as an intermediate between sulfite and cysteine (1, 2), possibly via a pathway involving cysteine-Ssulfonate as a direct precursor of cyst&e (24). Shepherd earlier had envisioned the u...

Desulfotomaculum thermobenzoicum, but not Desulfotomaculum nigrificans, Desulfotomaculum ruminis, or Desulfosporosinus orientis, grew by disproportionation of thiosulfate, forming stoichiometric amounts of sulfate and sulfide; sulfite was not disproportionated. The addition of acetate enhanced growth and thiosulfate disproportionation by D. thermobenzoicum compared to those observed with thiosu...

The phs chromosomal locus of Salmonella typhimurium is essential for the dissimilatory anaerobic reduction of thiosulfate to hydrogen sulfide. Sequence analysis of the phs region revealed a functional operon with three open reading frames, designated phsA, phsB, and phsC, which encode peptides of 82.7, 21.3, and 28.5 kDa, respectively. The predicted products of phsA and phsB exhibited significa...

The adsorption behavior of gold from copper–tartrate–thiosulfate solutions with ion-exchange resins was studied in this paper. Experimental parameters include resin dosage, pH, temperature, copper, tartrate, and thiosulfate concentration. A moderate increase tartrate concentration is beneficial for adsorption, but an excessive or higher temperature depresses the process. Increasing copper conce...

Thiosulfate-oxidizing sox gene homologues were found at four loci (I, II, III, and IV) on the genome of Bradyrhizobium japonicum USDA110, a symbiotic nitrogen-fixing bacterium in soil. In fact, B. japonicum USDA110 can oxidize thiosulfate and grow under a chemolithotrophic condition. The deletion mutation of the soxY(1) gene at the sox locus I, homologous to the sulfur-oxidizing (Sox) system in...

Thiobacillus neapolitanus, when grown in continuous culture with thiosulfate limiting growth, possessed an apparent maximal molar growth yield of 8.0 g (dry weight) per mole of thiosulfate. The substrate requirement for energy of maintenance was the highest yet reported, amounting to 21.8 mmoles of thiosulfate per g per hr. The molar growth yield, corrected for this maintenance energy requireme...

Seven mutants of Chlorella pyrenoidosa (Emerson strain 3) impaired for sulfate utilization have been isolated after treatment of the wild-type organism with nitrosoguanidine by replica plating on media containing thiosulfate and l-methionine. These mutants fall into three classes based on their ability to grow on sulfate, accumulate compounds labeled from sulfate-(35)S, and reduce adenosine 3'-...