This research includes synthesis of new heterocyclic containing (1,3-oxazepine) derivatives 6- methyl 2-thiouracil. The preparation process started by the reaction 2-thiouracil with ethyl chloroacete to give 2-((4-hydroxy-6-methylpyrimidin-2-yl) thio) acetate (1). Compound (1) reacted hydrazine hydrate 2-((4-hydroxy-6-methylpyrimidin-2-yl)thio) aceto hydrazide (2). That various substituted benz...

the electrochemical oxidation of methyl catechol in the presence of 2-thiouracil (as a nucleophile) has beenperformed in aqueous solutions using cyclic voltammetry and controlled-potential coulometric techniques.the electrochemical behavior of methyl catechol in the presence of 2-thiouracil was investigated. theelectrochemical synthesis of this compound has been successfully performed in an und...

Horseradish peroxidase (type VIII) catalyzed and electrochemical oxidations of 2-thiouracil have been studied in phosphate buffer of pH 7.20 (JL==l.O M) at an ambient temperature of 25±2°C. The peroxidase catalyzed oxidation has been initiated by using hydrogen peroxide and electrooxidation carried out at pyrolytic graphite electrode. The UV-absorbing intermediates generated in both the oxidati...

The incidence of granulocytopenia in a series of 5,745 cases of thiouracil administration has been reported to be 2.5%o,8 and clinical studies have suggested that pyridoxine in large doses is of value in restoring the blood picture to normal.' The present experiments were devised to determine (a) if granulocytopenia could be induced in pyridoxine-deficient and in adequately fed mice by the use ...