نتایج جستجو برای: thrombopoietin
تعداد نتایج: 1701 فیلتر نتایج به سال:
By Shirley Ebbe I T HAS BEEN CLEAR for almost 20 years that platelet production is subject to homeostatic regulatory mechanisms that result in stimulation when the platelet count is li w’ and suppression when it is high.2 In spite of elapsed time, the physiologic processes that are involved in those regulatory mechanisms are not clear. Thrombocytopoiesis may be regulated by a humoral thrombopoi...
Thrombopoietin bMpl ligand) has recently been purified and is considered to be the humoral regulator of platelet production. To see whether this molecule possessed the physiologic characteristics necessary t o mediate the feedback loop between blood platelets and the bone marrow megakaryocytes, we determined the relationship between blood levels of thrombopoietin and changes in the circulating ...
Our understanding of thrombopoiesis--the formation of blood platelets--has improved greatly in the last decade, with the cloning and characterization of thrombopoietin, the primary regulator of this process. Thrombopoietin affects nearly all aspects of platelet production, from self-renewal and expansion of HSCs, through stimulation of the proliferation of megakaryocyte progenitor cells, to sup...
Circulating thrombopoietin and interleukin-6 concentrations were investigated in two different settings of thrombocytopenia. Twenty patients with autoimmune thrombocytopenic purpura (ATP), 12 patients with aplastic anemia (AA) and 15 healthy subjects were studied. Thrombopoietin was significantly increased in AA and deficient in ATP. Interleukin-6 was significantly increased in ATP, compared to...
BACKGROUND Sepsis is still a major health problem that causes high mortality in all populations. Organ dysfunction including sepsis-associated thrombocytopenia is prevalent among sepsis patients, resulting in increasing mortality rates. Considering the clinical role of platelets, thrombocytopenia in sepsis has led to a large spend in research activity and clinical trials in this area, yet there...
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