INTRODUCTION Differential diagnosis of thrombotic microangiopathies can be difficult. Atypical hemolytic uremic syndrome is a rare, life-threatening disease caused by uncontrolled chronic activation of alternative complement pathway, resulting in microvascular thrombosis, organ ischemia and damage. Prognosis is poor: up to 65 percent of patients require dialysis or have kidney damage of varying...

Opana (oxymorphone) is a powerful semi-synthetic opioid agonist used for chronic pain management that is ingested orally. However, improper injection of Opana can lead to a rare and fatal blood disorder known as thrombotic microangiopathy. Opana-induced thrombotic microangiopathy can be easily mistaken for thrombotic thrombocytopenic purpura (TTP), leading to the initiation of therapeutic plasm...

Thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), and scleroderma renal crisis (SRC) all present with features of thrombotic microangiopathy. Distinguishing among these entities is critical, however, as treatments differ and may be mutually exclusive. We describe the case of a 25-year-old woman with an undefined mixed connective tissue disease who presented 6 weeks pos...

Introduction Thrombotic microangiopathy is a term for a morphologic lesion characterized by platelet and fibrin thrombi involving the microvasculature. The morphologic lesions thus overlap between hemolytic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP), and the lesions seen in scleroderma and malignant hypertension. HUS/TTP typically involves glomeruli and smaller vessels, whereas s...

We present a case of severe cardiovascular emergency in 21-year-old patient — malignant hypertension complicated by acute kidney injury and thrombotic microangiopathy.