A method for the synthesis of 1-(5-methyl-2-furoyl)thymine (7) and 1-(5-methyl-2-furyl)thymine (8) is described. Trimethylsilyliodide catalysed addition of 5-methyl-2,4-bis(trimethylsilyloxy)pyrimidine (9) to 2-methyl-2,5-dihydro-2,5-dimethoxyfuran yielded the new thymine derivative 13. Photooxidations of 7 and 8 gave not the expected addition products but furan endoperoxides and hydroperoxides...

The influence of ribo- and deoxyribonucleosides and ribo- and deoxyribonucleotides on the uptake of radiolabeled thymidine and thymine by Haemophilus influenzae during growth was investigated. A nucleoside-degrading enzyme similar to that reported in Escherichia coli was found to break down thymidine unless other nucleosides were present to divert its action. The presence of other nucleosides p...

The population and depopulation mechanisms leading to the lowest-lying triplet states of 2-Se-Thymine were studied at MS-CASPT2/cc-pVDZ level theory.

Pyrimidine hydrates are products of ultraviolet irradiation of DNA. We have already demonstrated the formation of both cis-thymine hydrate and trans-thymine hydrate (6-hydroxy-5,6-dihydrothymine) in irradiated poly(dA-dT):poly(dA-dT). These are released from DNA as free bases by bacterial or human glycosylases. Thymine hydrate stabilities were studied in irradiated DNA substrates using purified...

Doctor, V. M. (University of Texas, Houston). Microbiological assay for thymine using a mutant of Streptococcus faecalis. J. Bacteriol. 84:17-22. 1962.-A rapid microbiological assay procedure for the determination of thymine was devised. The test organism, Streptococcus faecalis Akt, a mutant of S. faecalis ATCC 8043, gives one-half the maximal growth response to 1.6 mug of thymine (assay range...

A combined theoretical and experimental study of the effect of microhydration on ionization energies (IEs) of thymine is presented. The experimental IEs are derived from photoionization efficiency curves recorded using tunable synchrotron VUV radiation. The onsets of the PIE curves are 8.85 +/- 0.05, 8.60 +/- 0.05, 8.55 +/- 0.05, and 8.40 +/- 0.05 eV for thymine, thymine mono-, di-, and trihydr...

The specific reaction of potassium permanganate with thymine in single-stranded DNA was employed to analyze thymine [2+2] dimer repair in DNA and in DNA/peptide nucleic acid hybrid duplexes. This simple and highly sensitive chemical assay is convenient for monitoring repair of thymine dimers in oligonucleotides.

It was observed that 10% of urine culture isolates of enterococci tested for antimicrobial susceptibility failed to grow on commercially prepared Mueller-Hinton agar with low levels of thymidine and thymine. All strains could utilize exogenous thymidine and thymine and required only low levels (0.4-microgram disk) to support growth. All thymidine-thymine-requiring strains were resistant to trim...