Recent studies in the field of autoimmune thyroid diseases have largely focused on the delineation of B-cell auto-epitopes recognized by the main autoantigens to improve our understanding of how these molecules are seen by the immune system. Among these autoantigens which are targeted by autoantibodies during the development of autoimmune thyroid diseases, thyroid peroxidase is a major player. ...

roid stimulating hormone in patients with Graves' disease is postulated by Purves and Adams. A similar lack of dependence on TSH is described by I. Doniach during rapid growth of the infantile thyroid and the compensatory hypertrophy of thyroid remnants after thyroidectomy. Interrelations of TSH and ACTH are correlated by Brown-Grant. His observations include the effects on thyroid activity of ...

Orbital 'auto-decompression' in TED (thyroid eye disease) is a well recognised phenomenon in older patients where lax orbital septa allow proptosis to decompress the orbit. Bony 'auto-decompression' in TED is a different entity which to the best of our knowledge has not been previously reported. We describe such a case which presented spontaneously, in the absence of trauma or bony pathology, a...

Early and late endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT). This review summarizes main endocrine disorders reported in literature and observed in our center as consequence of auto- and allo-HSCT and outlines current options for their management. Gonadal impairment has been f...

概 要 橋 本病 をは じめ とす る各種 甲状腺疾患患者血 中に証 明 され る甲状腺 自己抗 体の意義 については 今 日ほ とん ど明 らかに され てい ない.そ こで確 実 に診断 した 甲状腺 疾患患者343例 につG,血 中甲状 腺 自己抗体 をthyroglobulin 抗原 とす る沈降反応(PT),タ ンニン酸処理血球 に よる感作血 球凝 集 反応(TRC),お よび機 能亢進症 のmicrosome分 画を抗 源 とす る補 体結舎反応(M C F)の3法 に よ り測 定 し,臨 床症状,検 速査所 見,治 療,経 過,と くに甲状腺組織所 見 と対 比せ しめ,か か る血 中抗体 の臨 床的意義 につ き検 討を加 えた.血 中抗体陽性率 は甲状襟 疾患で他種疾患,健 康者に比 しい ち じる しく高 く,甲 状腺 疾患 では慢性甲状腺炎が抗体価 ともに...

The association between thyroid autoimmunity and thyroid cancer was carried out in a series of solitary thyroid nodules submitted to fine-needle aspiration cytology and subsequent histopathology. US guided FNACs were obtained from 295 unselected consecutive patients with single thyroid nodules and positive (98) or negative (197) serum anti-thyroid antibody. Cytological results were classified i...

Sickle cell anemia results from a single amino acid substitution in the gene encoding the β-globin subunit. Polymerization of deoxygenated sickle hemoglobin leads to decreased deformability of red blood cells. Hashimoto's thyroiditis is a common thyroid disease now recognized as an auto-immune thyroid disorder, it is usually thought to be haemolytic autoimmune anemia. We report the case of a 32...

A patient with chronic mild ulcerative colitis is described. Her illness was characterized by fluctuating blood eosinophilia, chronic persistent hepatitis and hypersensitivity to sulphasalazine. She subsequently developed auto-immune thyroid disease. The inter-relationships of these various disorders are discussed.

UNLABELLED BACKGROUND Lithium is an integral drug used in the management of acute mania, unipolar and bipolar depression and prophylaxis of bipolar disorders. Thyroid abnormalities associated with treatment with lithium have been widely reported in medical literature to date. These include goitre, hypothyroidism, hyperthyroidism and autoimmune thyroiditis. This current review explores the va...

The thyroid has been examined histologically in 77 cases of cirrhosis of the liver and in an equal number of control cases. Contrary to expectation, no difference was found between the incidence or the severity of lymphocytic infiltration of the thyroid in the two groups. A conspicuous fibrosis or ;cirrhosis' of the thyroid, not related to lymphocytic infiltration, was associated with cirrhosis...