Parotid metastasis originated from papillary thyroid carcinoma is extremely rare, especially as the first presentation of the disease. We present a 70-year-old man with a history of painless swelling in the right side of the neck. He was evaluated for parotid tumor and histopathologic examination revealed a poorly differentiated carcinoma in the parotid gland with suspicion of thyroid origin. T...

Papillary thyroid carcinoma (PTC) is one of the most commonly diagnosed types of differentiated carcinoma of the thyroid. It is stated that lung is the most common site of metastasis followed by bone. The incidence of paranasal sinus (PNS) metastasis is fairly uncommon in case of thyroid carcinoma. To the best of our knowledge, no case of metastatic PTC to nasal cavity has been reported. In thi...

Thyroid gland metastatic tumors are rare in clinical practice. Clear cell RCC is one of common metastatic tumors to thyroid. We here reported a case of incidentally found clear cell renal carcinoma metastasis to the thyroid gland 3 years after nephrectomy, in the thyroidectomy procedure performed for the patient due to the thyroid enlargement caused by multinodular goiter. A 65-year-old Iranian...

background: the phosphatidylinositol 3-kinase/akt signaling pathway is recognized as a key driver of cancer cell survival and proliferation, and is often contingent upon an impairment of expression/function of the pten tumor suppressor, a negative regulator of this pathway. in addition, the cytoskeletal signaling protein tensin 2 has also been implicated as a negative regulator of this pathway....

introduction: medullary thyroid carcinoma (mtc) is a rare thyroid cancer secreting calcitonin (ct) which is the most sensitive and specific tumor marker for mtc. this type of thyroid cancer is able to metastasize to different body areas including regional lymph nodes, lungs, liver and bone. the aim of this study was to assess the sensitivity and specificity of [99mtc-dmsa (v)] whole body scan (...

follicular thyroid carcinoma (ftc) is the second most common type of thyroid cancer after papillary carcinoma. it usually grows slowly and is clinically indolent; but rarely, its aggressive forms with distant metastases can occur. we report here an uncommon case of bilateral orbital metastasis of ftc. a 70-year-old woman presented with bilateral exophtalmus and past medical history of thyroid n...

the primary treatment of thyroid carcinoma is surgery and the outcome depends on its extent. the post-operative management alternatives in thyroid carcinoma include thyroid hormone, radio-iodine ablation (i-131 na), external beam radiation therapy (ebrt) and occasionally adjuvant chemotherapy. this retrospective study analyzes the managements of 153 patients (102, 51), age range 10-96 years, me...

anaplastic thyroid carcinoma is an uncommon, highly aggressive malignancy usually presenting in the elderly. an eighteen year old boy was recently diagnosed as anaplastic carcinoma of the thyroid.  pet/cect scan performed for staging, revealed a large fdg avid heterogeneously enhancing thyroid mass with bilateral jugular venous thrombosis, which also showed increased fdg uptake, thus pointing t...

introduction: considering the influence of geographical, genetic and ethnic factors on the prevalence of thyroid pathological lesions, this study was performed to assess the prevalence of pathological lesions in thyroid autopsic samples obtained from adult cadavers of isfahan forensic medical center. material and methods: in this study, 202 thyroid glands from cadavers with no evidence of thyro...

worldwide, thyroid cancers are the most common type of endocrine-related cancers. papillary carcinoma accounts for the most frequent type of thyroid malignancy. a rare variant of papillary carcinoma of the thyroid is the cribriform-morular variant. we report a case of solitary, cribriform-morularvariant of papillary carcinoma in a 55-year-old lady. it is important to identify this variant becau...