OBJECTIVE This study was designed to assess the efficiency of the serum thyrotropin to thyroglobulin ratio for thyroid nodule evaluation in euthyroid patients. STUDY DESIGN Cross-sectional study. SETTING Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China. SUBJECTS AND METHODS Retrospective analysis was performed for 400 previously untreated cases present...

in this study 93 hirsute females (ferryman and gallway score > 8) referred to institute of endocrinology & metabolism and office were assessed. baseline testosterone (tes), dehydroepiandrosterane sulfate (dhea-so4). follicular stimulating hormone (fsh). leuteinizing hormone (lh), prolactin (prl), thyroid stimulating hormone (tsh), baseline 17 hydroxyprogesterone (17 ohp) and in some cases acth ...

· Growth hormone (GH), which is essential for growth · Thyroid stimulating hormone (TSH), which regulates thyroid function · Prolactin (PRL), which is essential for lactation · Follicle stimulating hormone (FSH) and Luteinizing hormone (LH), which are essential for ovulation in female animals and sperm production in male animals · Adrenocorticotroph hormone (ACTH), which stimulates the adrenal ...

Unrecognized congenital hypothyroidism leads to mental retardation. Newborn screening and thyroid therapy started within 2 weeks of age can normalize cognitive development. The primary thyroid-stimulating hormone screening has become standard in many parts of the world. However, newborn thyroid screening is not yet universal in some countries. Initial dosage of 10 to 15 microg/kg levothyroxine ...

Serum thyroid stimulating hormone and thyroxine concentrations were monitored in 42 infants who had been treated for congenital hypothyroidism. Serum thyroid stimulating hormone concentrations were raised in 22 of the infants (52%) at 2 to 4 months, in 16 (38%) at 5 to 11 months, in 14 (33%) at 12 to 18 months, and in eight (19%) at 2 to 4 years. Serum thyroxine and the dose of L-thyroxine/kg/b...

Differential display (DD) PCR (Liang and Pardee, 1992) is a recently described technique to identify genes whose expression has changed during a biological process. We used this method to detect genes thyroid stimulating hormone-dependently regulated in a rat thyroid cell line, because thyroid stimulating hormone (TSH) is the most important hormone for cell proliferation and differentiation inc...

Thyroiditis is a general term that encompasses several clinical disorders characterized by inflammation of the thyroid gland. The most common is Hashimoto thyroiditis; patients typically present with a nontender goiter, hypothyroidism, and an elevated thyroid peroxidase antibody level. Treatment with levothyroxine ameliorates the hypothyroidism and may reduce goiter size. Postpartum thyroiditis...

Abstract Objective: Thyroid dysfunction complicates the metabolic derangement observed in Diabetes Mellitus (DM). It is necessary to recognize and treat it, when present, in order to achieve stability of metabolic control in these patients. The aim of this study was to investigate the effect of DM on thyroid hormone levels and other biochemical variables. Materials and Methods: To determine...

BACKGROUND Thyrotropin-producing pituitary tumor is relatively rare. In particular, concurrent cases associated with Graves' disease are extremely rare and only nine cases have been reported so far. We describe a case of a thyrotropin-producing pituitary adenoma concomitant with Graves' disease, which was successfully treated. CASE PRESENTATION A 40-year-old Japanese woman presented with mild...

Papillary thyroid cancer is a common endocrine malignancy. Although p21-activated kinase 4 (PAK4) is involved in the development of different types of tumor, its function has not been investigated in papillary thyroid cancer. Here, we identified a role for PAK4 in papillary thyroid cancer progression. Levels of PAK4 and PAK4 phosphorylated at serine 474 correlated significantly with tumor size ...