Many patients present to the surgical department with a thyroid nodule. However not all require surgery and only 5-6% of these are malignant. There are many methods to diagnose and predict malignancy in a thyroid nodule. This study throws light on the usefulness of TSH (thyroid stimulating hormone) estimation and its role in predicting malignancy. This is a prospective study involving 100 patie...

Two sisters with cretinism are reported. Each showed low levels of serum triiodothyronine, thyroxine, and thyroid-stimulating hormone (TSH). In the elder sister, serum TSH did not increase after administration of thyrotropin-releasing hormone. We conclude that cretinism in these 2 sisters was due to TSH deficiency. This is the second report of 'familial' pituitary cretinism (TSH-deficient conge...

The standard thyrotropin releasing hormone (TRH) test (200 μg) with synthetic TRH is no longer used commonly for the detection of primary hypothyroidism or hyperthyroidism. The reason has been that this test has been replaced by the development of more sensitive thyroid-stimulating hormone (TSH) assays, and hence suppression or elevation of TSH has been regarded as a sufficient criterion for th...

The thyroid stimulating hormone (TSH) assay measures the concentration of thyroid stimulating hormone in the serum. TSH assays have been classified by "generation" based on the functional sensitivity of the assay, i.e., the lowest concentration at which the assay is able to maintain an inter-assay precision, expressed in terms of percent coefficient of variation (%CV), of 20% or less. Virtually...

The dogma that thyroid-stimulating hormone (TSH) solely regulates the production of thyroid hormone from the thyroid gland has hampered research on its wider physiological roles. The action of pituitary TSH on the skeleton has now been well described; in particular, its action on osteoblasts and osteoclasts. It has also been recently discovered that the bone marrow microenvironment acts as an e...

Patients with resistance to thyroid hormone (RTH) exhibit elevated thyroid hormone levels and inappropriate thyrotropin (thyroid-stimulating hormone, or TSH) production. The molecular basis of this disorder resides in the dominant inhibition of endogenous thyroid hormone receptors (TRs) by a mutant receptor. To determine the relative contributions of pituitary versus hypothalamic resistance to ...

Abstract Objective: Thyroid dysfunction complicates the metabolic derangement observed in Diabetes Mellitus (DM). It is necessary to recognize and treat it, when present, in order to achieve stability of metabolic control in these patients. The aim of this study was to investigate the effect of DM on thyroid hormone levels and other biochemical variables. Materials and Methods: To determine...

SH is defined as a serum thyroid stimulating hormone (TSH) above the upper limit of the reference range, with a serum T4 and T3 thyroxine within the reference range. Other causes of a raised TSH such as a past history of thyroid disease and patients on T4 hormone treatment need to be excluded. Although patients with subclinical thyroid disease are usually asymptomatic, but nearly 30% have sympt...

Siskind and colleagues do not mention the impact of thyroid assays reference ranges on diagnosis management hypothyroidism.1 It is generally believed that assay differences are accounted for by specific intervals. We found, however, subclinical hypothyroidism (SCH) strikingly different depending stimulating hormone (TSH) free thyroxine …

 Background: To investigate thyroid function in preeclamptic patients in comparison with normal pregnant women. Methods: In this analytical cross-sectional study free Thyroxine (T4), and Thyroid Stimulating Hormone (TSH) levels were measured in 100 preeclamptic patients and were compared with Free T4 and TSH levels in 101 normal pregnant women in their third trimester of pregnancy. Patient...