Loss of heterozygosity of chromosome 3p21 is one of the most frequent alterations in solid tumors, including thyroid carcinomas. Recently, we have characterized the novel tumor suppressor gene RASSF1 located in this locus. The RASSF1A isoform is epigenetically inactivated in a variety of human primary tumors. In this study, we investigated the expression and methylation status of the RASSF1 gen...

BACKGROUND/AIMS Hyalinizing trabecular tumors are rare neoplasms of the thyroid gland often mistaken for thyroid carcinoma on fine-needle aspiration. We review the distinguishing characteristics of hyalinizing trabecular tumors and their management. METHODS We present the case of a patient diagnosed with papillary thyroid carcinoma on fine-needle aspiration as well as a review of the literatu...

WARNING: RISK OF THYROID C-CELL TUMORS See full prescribing information for complete boxed warning. • Liraglutide causes thyroid C-cell tumors at clinically relevant exposures in rodents. It is unknown whether Victoza causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans, as human relevance could not be determined by clinical or nonclinical studies (5.1). • Victoz...

Implants of dependent mouse pituitary thyrotropic tumors survived prolonged suppression of growth with thyroid hormone. With one dependent strain, 805~, no tumor became palpable after implantation in control mice with intact thyroid to 17 months. However, tumors regularly appeared in implanted radiothyroidectomized mice. The latent period to appearance of the tumor decreased with increasing tim...

CONTEXT Histologic examination of thyroid nodules is the current standard to distinguish benign from malignant thyroid epithelial tumors and to classify histologic subtypes. This review analyzes the problems in histological differential diagnosis as well as contradictions between histology and molecular data and describes possibilities to combine histology with molecular data in an effort to mo...

Despite that thyroid cancer accounts for over 90% of tumors that arise from the endocrine system, these tumors barely represent 2% of solid tumors in adults. Many entities are grouped under the general term of thyroid cancer, and they differ in histological features as well as molecular and clinical behavior. Thus, the prognosis for patients with thyroid cancer ranges from a survival rate of >9...

BACKGROUND Thyroid neoplasia is common in dogs, but there are few reports of dogs with ectopic, sublingual thyroid tumors. OBJECTIVES To describe clinical features and outcomes of dogs with ectopic, sublingual thyroid neoplasia. ANIMALS Five hundred and forty-four dogs with thyroid neoplasia. METHODS This retrospective study reviewed the medical records of dogs referred for thyroid neopla...

Oxyphilic tumors (oncocytomas or Hürthle cell tumors) form a rare subgroup of thyroid tumors characterized by cells containing abundant mitochondria. The relationship between the mitochondrial proliferation and the pathogenesis of these tumors is unknown. We have assessed the expression of the mitochondrial ND2 and ND5 (subunits of the nicotinamide adenine dinucleotide dehydrogenase complex) ge...

AIM The aim of this study was to describe the demographic characteristics and disease patterns among patients with thyroid nodular abnormalities (goiter) and benign tumors of the thyroid gland in Albania, a transitional country in South Eastern Europe. METHODS Our study included all patients diagnosed with goiter and/or benign tumors of the thyroid gland who were hospitalized at the Universit...

intra-operative management of thyroid gland in laryngeal cancer is controversial. to determine the rate of thyroid involvement in patients with laryngeal cancer treated by radical surgical excision, we reviewed the records during 1996-2000 in imam khomeini hospital, cancer institute, and amir alam hospital.we studied several factors such as age, gender, and tumor location, presence of thyroid i...