Multikinase inhibitors (e.g. Sorafenib), phosphodiesterase-5 inhibitors (e.g. Tadalafil), and endothelin-1 receptor blockers (e.g. Macitentan) exert influential protection in a variety of animal models of cardiomyopathy; however, their effects on thyroxin-induced cardiomyopathy have never been investigated. The goal of the present study was to assess the functional impact of these drugs on thyr...

1. Knoshi J, lida Y, Kousaka T, et al. Effect of antithyroxin autoantibodies on radioimmunoassay of free thyroxin in serum. Clin Chem 28, 1389-1391 (1982). Case report. 2. Mullinger RN, Walker G. Free thyroxin in thyroid disease. Clin Chem 28, 13941395 (1982). Letter. 3. Bhagat CI, Garcia-Webb P, Watson F, Beilby JP. Interference in radioimmunoassay of total serum thyroxin and free thyroxin due...

The influence of moderately diluted, agitated, i.e., homeopathically prepared, thyroxin solutions (10-11 - 10-21, final concentration in the basin water 0.6 10-15 - 0.6 10-25 parts by weight after the first application) on metamorphosis in highland Rana temporaria from the two-legged stage was studied. In accordance with the homeopathic idea of effects of specially prepared dilutions being inve...

It has been verified that endothelin-1 (ET-1) activates matrix metalloproteinase (MMP) in the process of myocardial remodeling. Sustained high thyroid hormone level gives rise to left ventricular hypertrophy, in which the ET-1 system is probably involved.We attempted to study the effects of CPU0213, a novel endothelin receptor antagonist, on myocardial remodeling induced by high dose L-thyroxin...

The basic theory of thyroxin-analog-based radioimmunoassays for free thyroxin has been extended to evaluate definitively the effects arising from residual binding of the tracer analog to serum proteins. Using experimentally determined binding constants and computer simulation techniques, we studied the effects of thyroxin-analog binding to serum proteins on results of Amerlex FT4 radioimmunoass...

1. It has been shown quantitatively that the degree of response of the hind limbs of tadpoles to the action of thyroxin is dependent upon the lengths of the limbs at the beginning of treatment. 2. Both the potency of the inducing substance and the rate of penetration of the substance into the animal might be involved in the effects of hydrogen ion concentration on induced development. 3. Change...

Serum biochemistry can be used for monitoring changes in the physiological condition of fish and water quality. The aim of this paper was to determine the concentrations of plasma T3 (Thyroid hormone), thyroxin, TSH (Thyroid-stimulating hormone), ALT (Alanine Aminotransferase), AST (Aspartate aminotransferase) and cholesterol of Liza klunzingeri caught on the northern side of the strait of Horm...

We describe two cases of fetal goiter in women with no history of thyroid disease. Diagnosis of fetal goiter during antenatal care was made by ultrasound and MRI. Congenital hypothyroidism was confirmed by fetal blood sampling that was treated with weekly intra-amniotic injections of L-thyroxin. One fetus was initially treated with four weekly intra-amniotic injections of 200 μgms of L-thyroxin...

We describe a double-antibody enzyme immunoassay for free thyroxin (FT4) in serum with use of beta-D-galactosidase conjugated to thyroxin. The method is uninfluenced by thyroxin-binding globulin or albumin. Values for FT4 so determined correlated well with those determined by radioimmunoassay (r = 0.98) and equilibrium dialysis (r = 0.89). The mean variability (CV) within and between assays was...

background: the secretion of thyroxin (t4) as the main hormone of thyroid gland is regulated by androgens. the present study aimed to evaluate the effect of testosterone and finasteride administration and castration on serum levels of t4 and to show the effect of this regulation on total body weight, weight of testis, and the weight of prostate. methods: male adult rats (n = 32) were divided in...