were marginally elevated and, as in frank thyrotoxicosis, Presented in part at the Sixth International Thyroid Conference, Vienna, Austria, July, 1970. Received for publication 22 March 1971 and in revised form 10 July 1972. T4-binding capacities of thyroxine-binding globulin (TBG) and thyroxine-binding prealbumin (TBPA) reduced, suggesting that subclinical thyrotoxicosis was present. Thus, the...

A 40-year-old hypothyroid female who had been treated with synthetic thyroxine was admitted to our hospital in October 1988 due to abnormal liver function tests. She had low serum free triiodothyronine (T3; 2.3 pg/ml) and high serum thyrotropin (TSH; 20.8 microU/ml) concentrations. On the other hand, the serum free thyroxine (FT4) level was inappropriately high, being 2.46 ng/dl. Immune precipi...

were marginally elevated and, as in frank thyrotoxicosis, Presented in part at the Sixth International Thyroid Conference, Vienna, Austria, July, 1970. Received for publication 22 March 1971 and in revised form 10 July 1972. T4-binding capacities of thyroxine-binding globulin (TBG) and thyroxine-binding prealbumin (TBPA) reduced, suggesting that subclinical thyrotoxicosis was present. Thus, the...

Reverse triiodothyronine (rT3), triiodothyronine (T3), thyroxine (T4), thyroxine binding globulin (TBG), and thyrotrophin (TSH) were measured in sera from placental cord blood in an unselected series of 272 deliveries. In this series the concentrations of rT3 (mean 3.33 nmol/l, 95% confidence limits 1.6--7.0 nmol/l), were log normally distributed and did not overlap the adult normal range (0.11...

Ligand binding characteristics of rat liver microsomal type I iodothyronine deiodinase were evaluated by measuring dose-response inhibition and apparent Michaelis-Menten or inhibitor constants of iodothyronine analogues to compete as substrates or inhibitors for the natural substrate L-thyroxine. These data show strong correlations with the binding requirements of hormone analogues to serum thy...

L-Thyroxine (L-T4), the naturally occurring thyroid hormone has been used for the treatment of thyroid dysfunctions, while D-T4 is not active in the thyroid and is used for the treatment of hyperlipidemia. Therefore, a convenient and reliable enantiomer separation method has been of great interest in the biological and pharmacological research field. Several groups reported the chromatographic ...

Problem statement: Thyroid dysfunction in pregnant women can influence the outcome for mother and fetus at all stages of pregnancy. As the fetus is entirely dependent on maternal thyroid hormones for its development until about 13 weeks of gestation, it is important to ensure adequate thyroxine substitution in pregnant women during the first trimester. The aim of this prospective study was to e...

Administration of the anticonvulsant 5,5-diphenylhydantoin sodium (DPH, Dilantin) depresses the level of serum protein-bound iodine (PBI) without inducing clinical hypothyroidism or changing other measures of thyroid function, such as 24-hour thyroidal accumulation of I131, thyroidal clearance of I131, serum cholesterol, and basal metabolic rate (1). Since DPH also induces a fall in the serum P...

background: the physiological changes in thyroid gland during pregnancy have been suggested as one of the pathophysiologic causes of preeclampsia. objective: the aim of this study was comparison of serum levels of tri?iodothyronine (t3), thyroxine (t4), and thyroid?stimulating hormone (tsh) in preeclampsia and normal pregnancy. materials and methods: in this case?control study, 40 normal pregna...

Some equilibrium dialysis determinations of free thyroxine (T4) vary directly with thyroxine-binding globulin (TBG) concentration. This apparent TBG dependence has been limited to methods involving radiolabeled T4 added to the dialysis system (tracer dialysis). In this study we compared tracer dialysis with direct dialysis for determining free T4 and obtained the following results (mean +/- SD)...