Minimally invasive osteosynthesis of proximal tibial fractures has grown in popularity in recent years. This article describes a patient with a Schatzker type VI proximal tibial fracture (AO/OTA type 41.C3) and previous compartment syndrome treated with definitive fixation 8 weeks after initial injury with a precontoured proximal tibial plate and a distal targeting device. Brisk bleeding occurr...

background: the treatment of open tibial fractures is still an orthopaedic challenge and full of complications. in many cases the use of external fixator that has been known as a non-:union: machine is obligatory with a high incidence of pin track infection and other complications. the aim of this study was to compare the use of external fixation as a definite method for treatment of open tibia...

Background. Injuries of the tibial nerve are a rather rare neuropathy of the peripheral nervous system. The tibial nerve may be injured at any point from the distal thigh to the foot. The most common causes of lesions include bone fractures, knee and ankle dislocations, wounds, compartment syndrome, and iatrogenic injuries. Material and methods. We studied 39 patients with tibial nerve injuries...

BACKGROUND Reperfusion aggravates nerve ischemic fiber degeneration, likely by the generation of reduced oxygen species. We therefore evaluated if racemic alpha-lipoic acid (LA), a potent antioxidant, will protect peripheral nerve from reperfusion injury, using our established model of ischemia-reperfusion injury. METHODS We used male SD rats, 300+/-5 g. Ischemia was produced by the ligature ...

abstract the leg is a complex district with functions of weightbearing support, stability, and motility. the management of extensive and complex defects is more challenging and often results in leg amputation or shortening. leg amputation is a severe mutilation that alters the patient’s work and social life by limiting ambulation and self-sufficiency. during a 3 years period we treated four pat...

Objective To evaluate the action of vanillin (Vanilla planifolia) on the morphology of tibialis anterior and soleus muscles after peripheral nerve injury. Methods Wistar rats were divided into four groups, with seven animals each: Control Group, Vanillin Group, Injury Group, and Injury + Vanillin Group. The Injury Group and the Injury + Vanillin Group animals were submitted to nerve injury by...

Peripheral nerve injury is typically associated with long-term disturbances in sensory localization, despite nerve repair and regeneration. Here, we investigate the extent of correct reinnervation by back-labeling neuronal soma with fluorescent tracers applied in the target area before and after sciatic nerve injury and repair in the rat. The subpopulations of sensory or motor neurons that had ...

The utilization of nerve transfer procedures in the upper extremity following brachial plexus injury, trauma, spinal cord tumors, infection or other etiologies are well established. Nerve injuries lower pose several additional challenges, including longer distance to target motor end plates, far-proximal lumbar pelvis, delayed presentation, and concomitant limb trauma. transfers have potential ...

Peripheral nerve injury alters the expression of hundreds of proteins in dorsal root ganglia (DRG). Targeting some of these proteins has led to successful treatments for acute pain, but not for sustained post-operative neuropathic pain. The latter may require targeting multiple proteins. Since a single microRNA (miR) can affect the expression of multiple proteins, here, we describe an approach ...