Citation: Mosing M, Böhm SH, Rasis A, Hoosgood G, Auer U, Tusman G, Bettschart-Wolfensberger R and Schramel JP (2018) Physiologic Factors Influencing the Arterial-ToEnd-Tidal CO2 Difference and the Alveolar Dead Space Fraction in Spontaneously Breathing Anesthetised Horses. Front. Vet. Sci. 5:58. doi: 10.3389/fvets.2018.00058 Physiologic Factors influencing the arterial-To-end-Tidal cO2 Differe...

Objective: Intermittent oscillatory flow has been reported experimentally to improve axial dispersion of respiratory gases by manipulating the flow waveform of oscillatory flow. We clinically investigated the improvement of high-frequency intermittent oscillation (HFIO). Methods: Seven male rabbits were anesthetized and controlled with conventional ventilation. Arterial blood gas was sampled to...

INTRODUCTION The present study is a pilot prospective safety evaluation of a new closed loop computerised protocol on ventilation and oxygenation in stable, spontaneously breathing children weighing more than 7 kg, during the weaning phase of mechanical ventilation. METHODS Mechanically ventilated children ready to start the weaning process were ventilated for five periods of 60 minutes in th...

BACKGROUND Periodic breathing (PB) during sleep and exercise in heart failure (HF) is related to respiratory acid-base status, CO2 chemosensitivity, and temporal dynamics of CO2 and O2 sensing. We studied inhaled CO2 and acetazolamide to alter these factors and reduce PB. METHODS AND RESULTS We measured expired and arterial gases and PB amplitude and duration in 20 HF patients during exercise...

Borland, Colin, Bryan Mist, Mariella Zammit, and Alain Vuylsteke. Steady-state measurement of NO and CO lung diffusing capacity on moderate exercise in men. J Appl Physiol 90: 538–544, 2001.—Using a rapidly responding nitric oxide (NO) analyzer, we measured the steady-state NO diffusing capacity (DLNO) from end-tidal NO. The diffusing capacity of the alveolar capillary membrane and pulmonary ca...

BACKGROUND In patients with chronic heart failure, abnormal ventilation at cardiopulmonary testing (expressed by minute ventilation-to-carbon dioxide production, or VE/VCO2 slope, and resting end-tidal CO2 pressure) may derive either from abnormal autonomic or chemoreflex regulation or from lung dysfunction induced by pulmonary congestion. The latter hypothesis is supported by measurement of pu...

We sought to characterize and quantify the performance of a portable dynamic end-tidal forcing (DEF) system in controlling the partial pressure of arterial CO2 (Pa(CO2)) and O2 (Pa(O2)) at low (LA; 344 m) and high altitude (HA; 5,050 m) during an isooxic CO2 test and an isocapnic O2 test, which is commonly used to measure ventilatory and vascular reactivity in humans (n = 9). The isooxic CO2 te...

BACKGROUND A non-invasive means of measuring pulmonary blood flow (PBF) would have numerous benefits in medicine. Traditionally, respiratory-based methods require breathing maneuvers, partial rebreathing, or foreign gas mixing because exhaled CO2 volume on a per-breath basis does not accurately represent alveolar exchange of CO2. We hypothesized that if the dilutional effect of the functional r...

BACKGROUND Patients undergone mechanical ventilation need rapid and reliable evaluation of their respiratory status. Monitoring of End-tidal carbon dioxide (ETCO2) as a surrogate, noninvasive measurement of arterial carbon dioxide (PaCO2) is one of the methods used for this purpose in intubated patients. OBJECTIVES The aim of the present trial was to study the relationship between end-tidal C...