The WD-40 repeat protein FAN binds to a distinct domain of the p55 receptor for tumor necrosis factor (TNF) and signals the activation of neutral sphingomyelinase (N-SMase). To analyze the physiological role of FAN in vivo, we generated FAN-deficient mice by targeted gene disruption. Mice lacking a functional FAN protein do not show any overt phenotypic abnormalities; in particular, the archite...

The present research focuses on a detailed facies description and interpretation of five alluvial fans of the Qazvin Plain. Beside the tectonic activity that leads to the localization of the fans on the northern margin of the Qazvin Plain, the climate has a significant role in the occurrence of their facies. The alluvial fans are divided into three facies groups: group 1, group 2, and group 3. ...

the aim of this paper is to evaluate the effect of tectonic on the volume of alluvial fans around danehkhoshk anticline. to achieve the purpose of this study, at first, borders, sweep angle(s) and radius(r) of alluvial fans were obtained based on quick bird satellite image and then difference in the altitude between the apex and toe of alluvial fans (h) were calculated based on topographic map ...

to increase agricultural crops’ quality and to minimize losses in the final product and used energy during the drying process, major drying system parameters should be continuously controlled. precise control of such parameters is attained by using automatic control systems. to optimize the overall dryer efficiency in a forced convective solar dryer, a controller was designed, constructed a...

Generation of proapoptotic sphingolipids by neutral sphingomyelinase activation is an early response to hypoxia/reoxygenation (HR) in cardiomyocytes. Factor associated with neutral sphingomyelinase activation (FAN) mediates activation of sphingomyelinase and subsequent apoptosis. However, the participation of FAN in HR-induced cardiomyocyte cell death has not been elucidated. We therefore inves...

Excessive coupling between object-oriented classes is widely acknowledged as a maintenance problem that can result in a higher propensity for faults in systems and a ‘stored up’ future problem. This paper explores the relationship between ‘fan-in’ and ‘fan-out’ coupling metrics over multiple versions of opensource software. More specifically, the relationship between the two metrics is explored...

Electric Fans are very commonly used in the industries, domestic applications and in tunnels for cooling and ventilation purposes. Fan parameters estimation is an important task as far as the reliable operation of a fan system is concerned. Basically, a fan is mainly consisting of a single phase induction motor and therefore fan system parameters are essentially the electrical parameters e.g. r...

The Gröbner fan of an ideal I ⊂ k[x1, . . . , xn], defined by Mora and Robbiano, is a complex of polyhedral cones in Rn. The maximal cones of the fan are in bijection with the distinct monomial initial ideals of I as the term order varies. If I is homogeneous the Gröbner fan is complete and is the normal fan of the state polytope of I. In general the Gröbner fan is not complete and therefore no...