Numerous specific age-related morbidities have been correlated with low intake and serum levels of tocopherols and tocotrienols. We performed a review in order to evaluate the extant evidence regarding: (1) the association between intake and serum levels of tocopherols and tocotrienols and age-related pathologies (osteoporosis, sarcopenia and cognitive impairment); and (2) the optimum diet ther...

Calcium carbonate (CaCO3) has been utilized as a pH-responsive component in various products. In this present work, palm tocotrienols-rich fraction (TRF) was successfully entrapped self-assembled oil-in-water (O/W) emulsion system by using CaCO3 the stabilizer. The droplet size, viscosity and tocotrienols entrapment efficiency (EE) were strongly affected varying processing (homogenization speed...

When most people think of vitamin E, more often than not they think of tocopherols—the most prominent being alpha-tocopherol. However, vitamin E refers to a family of eight distinct compounds: four tocopherols and four tocotrienols. While most people are familiar with alpha-tocopherol, other tocopherol forms include beta-, gamma-, and delta-. Similarly, the vitamin E family includes alpha-, bet...

Quantification of tocotrienols in human plasma is critical when the attention towards tocotrienols on its distinctive properties is arising. We aim to develop a simple and practical normal-phase high performance liquid chromatography method to quantify the amount of four tocotrienol homologues in human plasma. Using both the external and internal standards, tocotrienol homologues were quantifie...

Figure 1. Structures of the various tocopherol and tocotrienol vitamers. Introduction There are eight vitamers of vitamin E (alpha-, beta-, gamma-, and delta-tocopherols and the corresponding tocotrienols) (Figure 1), differing in their biological activity and distribution in foods. Most often vitamin E’s role is usually associated with its antioxidant activity. For example, α-tocopherol is a w...

Lipopolysaccharide (LPS) induces host inflammatory responses and tissue injury and has been implicated in the pathogenesis of various age-related diseases such as acute respiratory distress syndrome, vascular diseases, and periodontal disease. Antioxidants, particularly vitamin E, have been shown to suppress oxidative stress induced by LPS, but the previous studies with different vitamin E isof...

Three different HPLC detection systems were compared for the determination of tocopherols and tocotrienols in olive oil: fluorescence and diode array connected in series, ultraviolet, and evaporative light scattering. The best results were obtained with the fluorescence detector, which was successfully applied in the quantification of tocopherols and tocotrienols in 18 samples of Portuguese oli...

Tocochromanols (tocopherols and tocotrienols) are important lipid soluble antioxidants and are an essential part of the mammalian diet. Oilseeds are particularly rich in tocochromanols with an average concentration 10-fold higher than other plant tissues. Here we describe a systematic approach to identify rate-limiting reactions in the tocochromanol biosynthetic pathway, and the application of ...

Radiation-induced heart disease (RIHD) is a long-term side effect of radiotherapy of intrathoracic, chest wall and breast tumors when radiation fields encompass all or part of the heart. Previous studies have shown that pentoxifylline (PTX) in combination with α-tocopherol reduced manifestations of RIHD in rat models of local heart irradiation. The relative contribution of PTX and α-tocopherol ...