introduction: ultra low dose (uld) morphine induces hyperalgesia which is mediated by excitatory gscoupled opioid receptors. this study was designed to investigate the development of tolerance to hyperalgesic effect of morphine. also we attempt to seek possible similarity, in view of gs proteins, between hyperalgesic effect of uld and hyperalgesic effect after tolerance to hd. method: male wist...

The map and the model designed by a designer and presented to a manufacturer in the form of a map is the result of his knowledge and innovation. The manufacturer, in turn, uses his best effort to produce a part accordingly. However, because of production problems and raw material, producing a precise part is very difficult and costly. One of the most important problems in this regard is designi...

Objective(s): Central nucleus of amygdala (CeA) is the most important region for morphine-induced reward, and GABAergic system plays an important role on morphine reinforcement. The influence of CeA administration of GABAB receptor agonist and antagonist on the expression and acquisition of morphine-induced incentive tolerance using conditioned place preference (CPP) paradigm was investigated i...

the map and the model designed by a designer and presented to a manufacturer in the form of a map is the result of his knowledge and innovation. the manufacturer, in turn, uses his best effort to produce a part accordingly. however, because of production problems and raw material, producing a precise part is very difficult and costly. one of the most important problems in this regard is designi...

In this article I argue for the relevance of examining tolerance in Victorian literature its specificity and particularly as distinct from sympathy. Following a recent reconceptualization philosophy political theory, recovering roots Latin term tolerare , which means “to suffer,” endure,” suggest that novels explore cognitive, emotional, physical pains involved tolerance. studies thus add an im...

although inter-variety variability for salt tolerance has been reported in bread wheat plants, little information is available on the genetic control of ion contents and biomass yield under saline conditions. a diallel cross, including reciprocals of two salt tolerant, two moderately tolerant and two sensitive iranian and exotic bread wheat varieties, was analyzed to investigate the inheritance...

Background: Tolerance and dependence to anti-nociceptive effect of morphine restricted its use. Nowadays co-administration of morphine and other drugs suggests diminishing this tolerance. Baclofen is one of the drugs that may be beneficial in the attenuation of tolerance to morphine. Studies have shown that changes in transient receptor potential vanilloid type 1 (TRPV-1) expression during admi...