Dental root formation is a dynamic process in which mesenchymal cells migrate toward the site of the future root, differentiate and secrete dentin and cementum. However, the identities of dental mesenchymal progenitors are largely unknown. Here we show that cells expressing osterix are mesenchymal progenitors contributing to all relevant cell types during morphogenesis. The majority of cells ex...

AIM To present a case where a traumatized, immature tooth still showed capacity for continued root development and apexogenesis after root canal treatment was initiated based on an inaccurate pulpal diagnosis. SUMMARY Traumatic dental injuries may result in endodontic complications. Treatment strategies for traumatized, immature teeth should aim at preserving pulp vitality to ensure further r...

Tooth development undergoes a series of complex reciprocal interactions between dental epithelium and the underlying mesenchymal cells. Compared with the study in tooth crown formation, little is known about the molecular mechanism underlying the development of tooth roots. In the present study, we conditionally knock out β-catenin gene (Ctnnb1) within developing odontoblasts and cementoblasts ...

This study presents the expression pattern and functions of thymosin beta 10 (Tbeta10), a Tbeta4 homologue during the development of mouse lower first molars. An in situ signal of Tbeta10 was detected on embryonic day 10.5 (E10.5)-E15.5 mainly in dental mesenchymal cells as well as in dental epithelial cells, while Tbeta4 was expressed in dental epithelial cells. In the late bell stage, preodon...

This case report looks at a case of traumatic avulsion and subsequent apexification of a maxillary permanent incisor of a 6-year-old boy and a 10-year follow-up is reported. Treatment included apexification of the tooth with incomplete root formation using mineral trioxide aggregate and restoration of the immature root with a zirconia post and a coronal composite restoration. At the 10-year fol...

Autogenous transplantation is an economical as well as the most sorted option for the treatment of badly destroyed teeth when a suitable donor tooth is available. This paper presents successful auto transplantation of a mature mandibular right third molar (48) without anatomical variance is used to replace a grossly decayed mandibular right first molar (46). The mandibular first molar was nonre...

this case report presents an uncommon case of maxillary molar with two palatal root canals and an enamel pearl in the furcation area. the article discusses root canal complexities of maxillary second molars as well as possibility of coexisting anomalies in the region that makes radiographic interpretation difficult and compromises the success of endodontic treatment.