We have investigated the efficacy of conditioning skin Langerhans cells (LCs) with agents to promote tolerance and reduce inflammation, with the goal of improving the outcomes of antigen-specific immunotherapy. Topical treatments were assessed ex vivo, using excised human breast skin maintained in organ bath cultures, and in vivo in healthy volunteers by analysing skin biopsies and epidermal bl...

In this paper, we review the current management of allergic rhinitis and new directions for future treatment. Currently, management includes pharmacotherapy, allergen avoidance and possibly immunotherapy. The simple washing of nasal cavities using isotonic saline provides a significant improvement and is useful, particularly in children. The most effective medication in persistent rhinitis used...

Sir, Verruca vulgaris is a benign epithelial hyperplasia caused by human papilloma viruses that causes therapeutic problems, especially in immunocompromised patients. We report here 2 patients on continuous immunosuppressive medication with relapsing warts resistant to topical immunotherapy with diphenylcyclopropenone (DCP). As an alternative, occlusive treatment with 5% imiquimod cream was suc...

: Allergic rhinitis is a common and often distressing condition. Currently, treatment with nonsedating antihistamines, topical therapy, and immunotherapy are very effective. Despite this, intramuscular depot steroids are commonly used in clinical practice. Here, we present the case of a young woman who developed disfiguring scarring after a depot steroid injection. This case highlights the risk...

Background Allergy to pollen grass causes significant morbidity in Poland. Allergic rhinitis is a common condition which, at its most severe, can significantly impair quality of life despite treatment with antihistamines and topical nasal corticosteroids. The aim of the study was to evaluate the efficiacy of injection specific immunotherapy (SIT) mixture grass pollen allergoide at 20 000 AUM/ml...

Atopic dermatitis is a chronic inflammatory skin disease that affects large number of pediatric patients between 2 and 17 years age. Typical symptoms include intense itching, erythema, scaling the skin. has been found to be associated with decreased quality life for their families. Diagnosis made by clinical evaluation differential diagnosis other dermatologic diseases. Treatment based on sever...

Background: Narrow band Ultraviolet B (NBUVB) has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been used as immunotherapy or as a part of combination therapies. The aim of this study was to compare the clinical efficacy and safety of NBUVB and NBUVB plus topical calcipotriol in the treatment of generalized vitiligo.Methods: NBUVB phototherapy was...

BACKGROUND Despite recent significant therapeutic advances, vitiligo remains a clinical conundrum. Topical immunotherapy has been extensively tested in the treatment of various dermatologic disorders, especially those believed to have an immunologic basis. AIM To evaluate the role of topical diphenylcyclopropenone (DPCP) in the treatment of vitiligo. METHODS Nineteen patients with limited v...