BACKGROUND The aim of this study was to evaluate the efficacy of a topical hyaluronic acid (HA) gel preparation (0.2%) in the management of oral lichen planus (OLP). METHODS A total of 124 patients with erosive OLP participated in a randomized, placebo-controlled, double-blind trial to evaluate the efficacy of a topical HA preparation. Outcome measures included soreness relief following immed...

Topical antimicrobial agents provide an opportunity to prevent the spread of bacterial burden beyond critical colonisation and local infection, aid in the swift and effective management of systemic infection, reduce excessive and prolonged use of antibiotic therapy for people living with chronic wounds [1, 2], and reduce the risk of developing bacterial resistance associated with the use of ant...

Sir, Besides traditional topical and systemic pharmacological treatments for the therapy of vulvovaginal yeast and bacterial infections, numerous over-the-counter medicaments containing natural substances (e.g. tea tree oil, echinacea, sodium caprylate, propolis) are marketed. Patients often prefer alternative medicine and selfprescribe herbal-based products. We report here an unusual case of a...

BACKGROUND Topical anesthetics are commonly applied for a variety of indications. Several lidocaine-containing topical anesthetics are available for purchase over the counter (OTC). Recently, the authors' group has shown that there is great interindividual discrepancy in the manner in which lidocaine is absorbed and metabolized for even a single OTC product. OBJECTIVES The authors compare fiv...

reasonable adult dose and, for this child, 1 mg kg. There are no available data concerning the likely absorption of corticosteroid from a topical preparation such as Eumovate in a child of this age; however, it would be a coincidence if this event were not involved in the development of GPP in this case. While unlikely to be a common occurrence in everyday clinical practice it does appear that ...

Uremic pruritus is a common and distressing symptom that affects more than 40% of patients undergoing hemodialysis. Several medications as well as topical preparation have been used for relief this condition. Sambucus ebulus has been shown anti-inflammatory and wound healing effects. In this research, the antipruritic effect of S. ebulus fruit extract was evaluated on patients with uremic pruri...

Background and objectives: Skin hyperpigmentation usually indicates an increase in production and accumulation of melanin. Hyperpigmentary disorders are characterized by the appearance of melasma, freckles and lentigo on the skin surface which can cause psychological disturbances. Herbal products could be extensively preferable due to their widespread accessibility and the vast...

OBJECTIVE To assess the ability of a topical preparation of glucosamine sulfate and chondroitin sulfate to reduce pain related to osteoarthritis (OA) of the knee. METHODS Sixty-three patients were randomized to receive either a topical glucosamine and chondroitin preparation or placebo to be used as required over an 8 week period. Efficacy was assessed using a visual analog scale (VAS) for pa...

abstractpaederus dermatitis is an irritant contact dermatitis due to accidental contact by a beetle belonging to the genus paederus. in this study, clinical efficacies of s. ebulus fruit extract solution in patients affected by paederus dermatitis were evaluated. a randomized double-blind, prospective, placebo-controlled clinical trial was performed in 62 patients with clinical symptoms and sin...