CONTEXT In most countries, the use of topical nasal decongestants is limited to a maximum of 10 days because of the risk of developing rebound mucosal swelling and rhinitis medicamentosa. OBJECTIVE To determine whether topical nasal decongestants can be safely used for 10 days in patients with chronic inflammation of the nasal mucosa. DESIGN Double-blind, randomized, controlled, parallel st...

We examine the progress that has been made towards the development of topical treatments for premature ejaculation (PE). Although generally regarded as one of the most common male sexual problems, the lack of approved pharmacological agents for PE means that treatment options are limited to behavioural therapy, where available, and the use of drugs 'off-label'. There are various theories on the...

Eutectic Mixture of Local Anaesthetics (EMLA) is recommended for use off-label as a treatment for premature ejaculation (PE). Other topical anaesthetics are available, some of which have been evaluated against oral treatments. The purpose of this systematic review was to evaluate the evidence from randomised controlled trials (RCTs) for topical anaesthetics in the management of PE. Bibliographi...

UNLABELLED The development and subsequent deterioration of diabetic foot ulceration (DFU) is a common occurrence across all healthcare divides, concerning all patient groups, age, gender and social environments. It increases demand on clinical resources and creates unnecessary hardship for patients. Chronic DFU is challenging to prevent and notoriously difficult to manage owing to the complex n...

A recent review suggested using topical pharyngeal anaesthesia only in patients who prefer to be endoscoped without sedation. Topical anaesthesia was also found to be unnecessary in sedated patients in a subsequent study'. However the mean (range) dose of midazolam given to patients in this study was 8 mg (4-10). Using a lower dose of midazolam (mean dose = 5.2 mg ± 0.5 (2SEM) ), lignocaine spr...

CASE REPORT An 82-year-old white woman with a history of hypertension, paroxysmal atrial tachycardia, and hypothyroidism underwent laparoscopic left adrenalectomy for possible adrenal carcinoma. On the third postoperative day, the patient’s course was complicated by a paralytic ileus. A nasogastric tube was placed, preceded by a 3-second dose of Hurricane spray (20% benzocaine, approximately 60...

BACKGROUND Chronic fatigue syndrome (CFS) is a disabling illness of persistent fatigue. Recent studies have shown that patients with CFS have an increased prevalence of nonallergic rhinitis. Inflammation of the nasal passages due to allergic rhinitis can cause nasal congestion resulting in an increased number of sleep disturbances and daytime fatigue. While topical nasal corticosteroids have be...

Cidofovir is a new class of antiviral agent with potent in vitro and in vivo activity against a broad spectrum of herpes viruses. The aim of this work was to obtain a prolonged therapeutic effect of cidofovir in the basal epidermis after its topical application. For this purpose, poly(lactide-co-glycolide) (PLGA) microparticles were prepared by solvent evaporation and spray-drying methods. Micr...

Introduction: Lidocaine is a class of Ib antiarrhythmic agent which available in various intravenous (IV) and topical forms. Systemic toxicity lidocaine has been reported following its IV injection or local infiltration for anesthesia, mostly. However, the application gel oral spray also possible. Manifestations induced systemic include neurologic cardiac symptoms. Reported cases after ingestio...