Dystonia has been described as a potential toxicity of radiation therapy. Management of this rare movement disorder is targeted in symptom improvement. We report a case of a 46-year-old female patient who developed dystonia during treatment of melanoma metastatic to the brain and discuss potential causes of and therapies for this rare complication.

We present a case series of four previously healthy, employed adults without significant prior medical history in each of whom symptoms developed while on fluoroquinolones (FQs), with progression that continued following discontinuation evolving to a severe, disabling multisymptom profile variably involving tendinopathy, muscle weakness, peripheral neuropathy, autonomic dysfunction, sleep disor...

Introduction Anti-arrhythmic drug therapy carries an understood risk for toxic side effects, even at therapeutic doses. In cases of high dose ingestion these toxic effects can present rapidly with extra-cardiac symptoms, malignant arrhythmias and lifethreatening hemodynamic deterioration. Prescribing clinicians should maintain familiarity with the mechanisms and kinetics of the anti-arrhythmic ...

serious toxicity other than some nausea. Continued treatment with intravenous theophylline resulted in compensation of her respiratory difficulties. In its literature, Clinical Assays mentions that 8-chlorotheophylline may interfere. Dimenhydrinate is the 8chlorotheophylline salt of the antihistaminic diphenhydrammne. In addition to the theophylline peak on chromatography, there was another pea...

Although locoregional relapse is frequent after definitive radiotherapy (RT) or multimodal treatments, re-irradiation is only performed in few patients even in palliative settings like e.g. vertebral metastasis. This is most due to concern about potentially severe complications, especially when large volumes are exposed to re-irradiation. With technological advancements in treatment planning th...

BACKGROUND Locally advanced and recurrent rectal cancers frequently cause pelvic morbidity including pain, bleeding and mass effect. Palliative pelvic radiotherapy is used to relieve these symptoms and delay local progression. There is no established optimal radiotherapy regimen and clinical practices vary. Our aim was to review the efficacy and toxicity of palliative pelvic radiotherapy of sym...

The effective development of new drugs relies on the identification of genes that are related to the symptoms of toxicity. Although many researchers have inferred toxicity markers, most have focused on discovering toxicity occurrence markers rather than toxicity severity markers. In this study, we aimed to identify gene markers that are relevant to both the occurrence and severity of toxicity s...

objective: medically unexplained symptoms are physical symptoms, which cannot be explained by organic ‎causes. this study aimed to investigate mental health in patients with medically unexplained ‎physical symptoms. ‎ method: one hundred outpatients who were admitted to the electro diagnosis clinic of imam khomeini ‎hospital, ahvaz/iran, participated in this study. data were collected using phy...

context worldwide prevalence of respiratory diseases, suffering from such diseases, and heavy cost of treatment, which all may result from lack of etiological understanding of these diseases in modern medicine, were the main factors to conduct the current study. in the present study, the causes and symptoms of asthma were evaluated and compared with those of some other respiratory diseases. ira...

introduction : although oral cancer is amenable for early detection, it often presents as advanced disease in many of patients. long-lasting ulcer or mucosal discoloration has been described as the key to an early diagnosis; however other symptoms may also exist. the present study aims to describe the frequency of the early symptoms in oral cancer patients, with a special focus on pain. materia...