background: thrombolytic therapy is the only approved treatment for acute cerebral ischemia. the hemorrhagic transformation is the greatest complication of this treatment, which may occur after recanalization of occluded artery. the aim of this study was to determine factors associated with clinical improvement and worsening in patients with acute ischemic stroke treated with intravenous thromb...

The present study was aimed to evaluate the protective effects of Hydroethanolic Murraya koenigii leaves extract (HEMKLE) against DMBA/TPA-induced angiogenesis, hepatotoxicity and renal toxicity during skin carcinogenesis in mice. For study, male LACA mice were divided into four groups: Group I (C), II (DMBA/TPA), III (HEMKLE), IV (HEMKLE+DMBA/TPA). 7, 12-dimethylbenz(a) anthracene (DMBA), 12-O...

stroke is an important cause of disability and death worldwide, with the majority of strokes occurring in older people. thrombolysis with recombinant tissue plasminogen activator (r-tpa) is the approved treatment for acute ischemic stroke. a major concern of physicians, who treat acute ischemic stroke with recombinant tissue plasminogen activator (r-tpa,) is the risk of intracerebral hemorrhage...

Mouse cerebellar cells in culture secrete tissue plasminogen activator (tPA) into the culture medium. Fibrin overlays have shown tPA to be associated with granule neurons in these cultures. This cell associated tPA can be displaced by extensive washing of the cells or by a brief lowering of the pH (less than 4), which leads to a loss of fibrinolytic activity by the cells. Incubation of these fi...

tissue plasminogen activator (tpa) is a serine protease, which is composed of five distinct structural domains with 17 disulfide bonds, representing a model of high-disulfide proteins in human body. one of the most important limitations for high yield heterologous protein production in escherichia coli (e. coli) is the expression of complex proteins with multiple disulfide bridges. in this stud...

The effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on myeloid colony formation were investigated by initial and delayed addition of TPA to the cultures. In the human placental condi tioned medium-stimulated cultures, TPA inhibited normal myeloid colony formation without any change in colony morphology when added at the beginning of culture. However, macrophage-like transformation of myel...

BACKGROUND AND PURPOSE We sought to evaluate the effects of administration of microbubbles (MBs) on the beginning, speed, and degree of middle cerebral artery (MCA) recanalization during systemic thrombolysis and continuous 2-MHz pulsed-wave transcranial Doppler (TCD) monitoring. METHODS We evaluated 111 patients with acute stroke attributable to MCA occlusion treated with intravenous tissue ...

The effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) on myeloid colony formation were investigated by initial and delayed addition of TPA to the cultures. In the human placental conditioned medium-stimulated cultures, TPA inhibited normal myeloid colony formation without any change in colony morphology when added at the beginning of culture. However, macrophage-like transformation of myelo...

Coupling tissue-type plasminogen activator (tPA) to carrier red blood cells (RBC) prolongs its intravascular life span and permits its use for thromboprophylaxis. Here, we studied the susceptibility of RBC/tPA to PA inhibitors including plasminogen activator inhibitor-1 (PAI-1) that constrain its activity and may reduce the duration of its effect. Despite lesser spatial and diffusional limitati...