We evaluated the effects of topiramate (TPM) on memory function in the intracarotid amobarbital (Wada) test in nine patients with mesial temporal lobe epilepsy (MTLE) whose antiepileptic drugs (AEDs) included TPM and compared their scores with those of 16 patients with MTLE on AEDs not including TPM. Sodium amobarbital was injected first into the hemisphere ipsilateral to the seizure focus and ...

Background Topiramate (TPM) is suggested to be a promising medication for treatment of methamphetamine (METH) dependence, but the molecular basis remains to be elucidated. Methods Among 140 METH-dependent participants randomly assigned to receive either TPM (N = 69) or placebo (N = 71) in a previously conducted randomized controlled trial, 50 TPM- and 49 placebo-treated participants had a tot...

Information security presents a huge challenge for both individuals and organizations. The Trusted Computing Group (TCG) has introduced the Trusted Platform Module (TPM) as a solution to end-users to ensure their privacy and confidentiality. TPM has the role of being the root of trust for systems and users by providing protected storage that is accessible only within TPM and thus, protects comp...

Topiramate (TPM) is an antiepileptic drug also used in migraine prophylaxis (Silberstein et al. 2007). Neuropsychiatric symptoms may emerge during the use of TPM (Fröscher et al. 2005). There are few reports showing a link between psychotic adverse events and use of TPM (Khan et al. 1999). Only one patient with schizoaffective disorder has been reported in the litera ture, who complained of dos...

RATIONALE The relationship between topiramate (TPM) concentration, dosage and adverse events in patients with epilepsy is still controversial. We therefore performed a prospective study in patients with poorly controlled epilepsy treated with TPM, predominantly in combination with other antiepileptic drugs. The goal of the study was to investigate the relationship between the occurrence of adve...

traditional medicines, according to the world health organization, are defined as “the sum total of the knowledge, skill, and practices based on the beliefs, theories, and experiences indigenous to different cultures that are based and developed historically. due to the increasing uses of traditional medicines worldwide, it seems that cognition of their principles and foundations are necessary....

Topiramate (TPM) is one of the novel antiepileptic drugs and exhibits a wide range of mechanisms of action. Efficacy of TPM has been demonstrated in partial-onset seizures and primary generalized seizures in adults and children, as both monotherapy and adjunctive therapy. More recently, TPM has been proposed as an add-on treatment for patients with lithium-resistant bipolar disorder, especially...

Topiramate (TPM) is one of the novel antiepileptic drugs and exhibits a wide range of mechanisms of action. Efficacy of TPM has been demonstrated in partial-onset seizures and primary generalized seizures in adults and children, as both monotherapy and adjunctive therapy. More recently, TPM has been proposed as an add-on treatment for patients with lithium-resistant bipolar disorder, especially...

OBJECTIVE To investigate the effects of topiramate (TPM), zonisamide (ZNS), and levetiracetam (LEV) on cognitive network activations in patients with focal epilepsy using an fMRI language task. METHODS In a retrospective, cross-sectional study, we identified patients from our clinical database of verbal fluency fMRI studies who were treated with either TPM (n = 32) or ZNS (n = 51). We matched...

BACKGROUND Topiramate (TPM) decreases tumor necrosis factor-alpha (TNF-α) and oxidative stress. We investigated protective effects of TPM on cell damage in kidney tissue during ischemia-reperfusion (I/R) damage. METHODS A total of 30 male Wistar albino rats were divided into three groups: control, I/R, and I/R plus TPM (I/R+TPM). Laparotomy without I/R injury was performed in control group. A...