BACKGROUND Compromised barrier function and intestinal inflammation are common complications of total parenteral nutrition (TPN). OBJECTIVE We tested the hypothesis that the lack of enteral nutrients in TPN might select commensal or pathogenic bacteria that use mucus as a substrate, thereby weakening the protection provided by the intestinal mucus layer. DESIGN Ileal microbiota profiles of ...

BACKGROUND In clinical settings, early total enteral nutrition (TEN) is known to reduce the postoperative complication and infection rate as well as duration of postoperative stay compared with total parenteral nutrition (TPN) in a variety of critical conditions. We aimed to compare effects TEN and TPN on wound healing and explore its possible mechanisms using rat model. METHODS Seven days af...

Total parenteral nutrition (TPN) leads to a shift in small intestinal microbiota with a characteristic dominance of Proteobacteria This study examined how metabolomic changes within the small bowel support an altered microbial community in enterally deprived mice. C57BL/6 mice were given TPN or enteral chow. Metabolomic analysis of jejunal contents was performed by liquid chromatography/mass sp...

Hepatic steatosis frequently complicates total parenteral nutrition (TPN). Some of the mechanisms responsible were examined in rats receiving calories as dextrose (CHO-TPN) or dextrose plus lipid emulsion (Lipid-TPN). Hepatic triglyceride content increased approximately threefold after CHO-TPN and twofold after Lipid-TPN (P less than 0.02). Hepatic triglyceride fatty acid composition reflected ...

Abstract. Time Petri Nets (TPNs) are a popular Petri net model for specification and verification of real-time systems. A widely applied method for analyzing Petri nets is component-level reduction analysis. The existing technique for component-level reduction analysis transforms a TPN component to a constant size of simple one while maintains the net external observable timing properties, but ...

BACKGROUND & AIMS Total parenteral nutrition (TPN), a crucial treatment for patients who cannot receive enteral nutrition, is associated with mucosal atrophy, barrier dysfunction, and infectious complications. Glucagon-like peptide-2 (GLP-2) and epidermal growth factor (EGF) improve intestinal epithelial cell (IEC) responses and attenuate mucosal atrophy in several TPN models. However, it remai...

Total parenteral nutrition (TPN), or the complete absence of enteral nutrients, is commonly used in a clinical setting. However, a major consequence of TPN administration is the development of mucosal atrophy and a loss of epithelial barrier function (EBF); and this loss may lead to an increase in clinical infections and septicemia. Our laboratory has investigated the mechanism of this TPN-asso...

In this paper, we consider bounded Time Petri Nets where time intervals (strict and large) are associated with places (P-TPN), arcs (A-TPN) or transitions (T-TPN). We give the formal strong and weak semantics of these models in terms of Timed Transition Systems. We compare the expressiveness of the six models w.r.t. (weak) timed bisimilarity (behavioral semantics). The main results of the paper...

In this paper, we consider safe Time Petri Nets where time intervals (strict and large) are associated with places (P-TPN), arcs (A-TPN) or transitions (T-TPN). We give the formal strong and weak semantics of these models in terms of Timed Transition Systems. We compare the expressiveness of the six models w.r.t. (weak) timed bisimilarity (behavioral semantics). The main results of the paper ar...