amorpha-4, 11-diene synthase (ads) gene is the first and important gene in artemisinin biosynthesis pathway that why for many researchers, the study of how to regulate of this gene is important. transcription factors can change the expression rate of several genes simultaneously. in this study, six wild accessions of artemisia annua, collected from golestan province, were used. many known trans...

objective(s): breast cancer is the most common type of cancer among women worldwide. this study investigated the expression and clinical significance of activating transcription factor 3 (atf3) in human breast cancer and its relationship with the clinical outcome of breast cancer.   materials and methods : atf3 expressions were detected in 114 primary breast cancer tissues and 114 adjacent norm...

background: metabolic syndrome (mets) is a prevalent disorder in pediatric age groups, described by a combination of genetic and environmental factors. sterol regulatory element‑binding transcription factor 1 (srebf‑1) induces the expression of a family of genes involved in fatty acid synthesis. moreover, dysregulation of mir‑33b, which is located within the intron 17 of the srebf‑1 gene, disru...

a member of homeodomain protein namely tgif2lx has been implicated as a tumor suppressor gene in human malignancy as well as in spermatogenesis. however, to our knowledge, dynamic functional evidence of the tgif2lx has not yet been provided. the aim of the present study was to investigate the human tgif2lx target gene(s) using a cdna-aflp as a differential display method. a pegfp-tgif2lx constr...

manipulation of stress related transcription factors to improve plant stress tolerance is a major goal of current biotechnology researches. myc2 gene encodes a key stress-related transcription factor involved in jasmonate (ja) and abscisic acid (aba) signaling pathways in arabidopsis. brassica napus, as a globally important oilseed crop, is a close relative of arabidopsis.  in the present study...

R ecently, Grant et al. (1) reported an association between type 2 diabetes and variation in the transcription factor 7-like 2 (TCF7L2) gene. Thereafter, the relation has been replicated in several populations (2–11). The mechanisms by which TCF7L2 variants contribute to the development of type 2 diabetes are incompletely understood. To gain insight on potential mechanisms, we examined the effe...