interferons (ifns) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. although ifns have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. ifns exert their pleiotropic effects through their multisubunit cell surface recept...

Objective(s): We previously reported a series of quinazoline derivatives as vascular-targeting anticancer agents. In this study, we investigated the mechanism underlying the anti-angiogenic activity of the quinazoline derivative compound 11d. Materials and Methods: We examined the effects of quinazoline derivative 11d on vascular endothelial growth factor receptor-2 (VEGFR2) activation via VEG...

Cells respond to pathogen infection by activating a complex innate immune signaling pathway, which culminates in the activation of transcription factors and secretion family functionally genetically related cytokines. However, excessive may cause tissue damage detrimental effects on host.

objective(s): we previously reported a series of quinazoline derivatives as vascular-targeting anticancer agents. in this study, we investigated the mechanism underlying the anti-angiogenic activity of the quinazoline derivative compound 11d. materials and methods: we examined the effects of quinazoline derivative 11d on vascular endothelial growth factor receptor-2 (vegfr2) activation via vegf...

the objective of this study was to observe the apoptosis-inducing effect and mechanism of baicalin on human cervical cancer hela cells. the inhibitory effect of baicalin on the growth of hela cells was measured by mtt assay, and cell proliferation and migration was analyzed by cell scratch assay. morphological changes of apoptotic cells were viewed by the light microscope and electron microscop...

Adult neurogenesis is a process of producing nerve cells from their progenitor that occurs in some areas in the brain such as the hypothalamus. Low activity in this area plays a role in neural degeneration and diseases such as multiple sclerosis, epilepsy and depression. MS is a neurodegenerative disease with a permanent disability that the main reason for it is axonal degeneration and neuronal...

materials and methods an oligogearray® (an oligonucleotide-based gene expression array platform) containing 126 wnt signaling pathway-related genes was used to compare gene expressions between primary hcc and adjacent non-tumorous liver tissues from 10 patients with hcc. selected differential genes were identified with real-time rt-pcr and immunohistochemistry (ihc). in particular, the protein ...

Background & Aims: Allergic diseases have increased in the last decade worldwide and researchers have been trying to introduce new strategies and drugs to treat these types of diseases. Nicotine shows anti-inflammatory properties and the studies have revealed that it can reduce the inflammation and the allergic responses. The mammalian target of rapamycin (mTOR) is a multifunctional protein kin...

adult neurogenesis is a process of producing nerve cells from their progenitor that occurs in some areas in the brain such as the hypothalamus. low activity in this area plays a role in neural degeneration and diseases such as multiple sclerosis, epilepsy and depression. ms is a neurodegenerative disease with a permanent disability that the main reason for it is axonal degeneration and neuronal...

background: gastric cancer (gc) is widely associated with chronic inflammation. the pro inflammatory microenvironment provides conditions that disrupt stem/progenitor cell proliferation and differentiation. the signal transducer and activator of transcription- 3 (stat3) signaling pathway is involved in inflammation and also contributes to the maintenance of embryonic stem cell (escs) pluripoten...