The wound healing process in skin is studied in human subjects treated with fractional photothermolysis. In-vivo histological evaluation of vacuoles formed over microthermal zones (MTZs) and their content is undertaken. A 30-W, 1550-nm single-mode fiber laser system delivers an array of 60 microm or 140 microm 1e2 incidence microbeam spot size at variable pulse energy and density. Treatments sp...

Vol. 28, No. 4, 2016 501 Received September 19, 2014, Revised May 11, 2015, Accepted for publication July 23, 2015 Corresponding author: Sung Ku Ahn, Department of Dermatology, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju 26426, Korea. Tel: 82-33-741-0621, Fax: 82-33-748-2650, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creativ...

APD: acquired perforating dermatosis CRF: chronic renal failure DM: diabetes mellitus EPS: elastosis perforans serpiginosa ESRD: end-stage renal disease RPC: reactive perforating collagenosis INTRODUCTION Perforating dermatosis is a heterogeneous group of disorders characterized by transepidermal elimination of dermal components such as collagen, elastin, or fibrin. Acquired perforating dermato...

Acquired perforating dermatosis (APD) is an uncommon skin disorder seen in majority among patients with chronic kidney disease and also in those with diabetes mellitus. We present the clinicopathological features of APD in a 65-year-old patient with diabetes mellitus and end-stage kidney disease on hemodialysis and review the recent advances in the management of APD, as well as the mechanisms o...

Breast cancer is the most common cause of cutaneous metastases from internal malignancies. Generally, the neoplastic cells are located in the dermis or hypodermis, while a finding of transepidermal elimination on cutaneous metastases is exceptional. In this report we present a patient with perforating cutaneous metastases from breast cancer with mucin 1 expression. Cutaneous, bone, lung, and he...

Acquired perforating collagenosis (APC) is a rare perforating dermatosis characterized by transepidermal collagen elimination. We describe a 65-year-old patient, with long-standing type 2 diabetes mellitus and a 2-year history of itchy hyperkeratotic nodules situated on the back, who was subsequently diagnosed with APC. Treatment included topical corticosteroids and antihistamines, without impr...

A 59-year-old man with chronic renal failure and diabetes mellitus presented with pruritic crusted lesions which histologically were perforating disorders, showing features of both Kyrle disease and acquired perforating collagenosis. The mechanisms of transepidermal elimination and the classification of perforating disorders are briefly discussed. Additionally, we question the concept of perfor...

Acquired perforating dermatosis (APD) is a rare disorder characterized by transepidermal elimination of contents from dermis with minimal disruption of surrounding structures, believed to be due to altered expression of dermal proteins. Its occurrence in patients with systemic mycosis has never been reported. We report a 60-y gentleman who presented with features of adrenal insufficiency (nause...