a large number of simple or complex translocation involving the cml and aml chromosomal abnormalities has been described. this study was aimed to investigate the complex chromosome aberrations in the series of myeloid malignancies including cml and aml. the present report deals analyzed 187 consecutive with cml and aml patients, using methotrexate  cell synchronization and  un-stimulated cultur...

background: carriers of translocations may have an increased risk of an unbalanced progeny due to imbalances and delays in meiosis. case: a 24-year-old pregnant iranian female was referred to the genetic department of yazd clinical and research centre for infertility because of her pregnancy history. she had three previous pregnancies, two of which ended in abortion. the one live born infant wa...

heavy metals such as cadmium mainly enter in the environment and ecosystem as a result of human activities. this study was conducted in order to evaluate the ability of bacterial inoculants to enhance efficiency of phytoextraction in a calcareous soil. three plants (amaranthus retroflexus, helianthus annus and medicago sativa), along with three levels of inoculants and four levels of cd were ev...

plant-based remediation (i.e. phytoremediation) is one of the most significant eco-sustainable techniques to cope with devastating consequences of pollutants. in the present study, the potential of a wetland macrophyt (i.e. potamogeton crispus ) for the phytoremediation of heavy metals (i.e. cu, cr, pb, as and cd) in the anzali wetland was evaluated. the results showed that p. crispus tends to ...

in the present study, a field study was performed on some herbaceous plants growing in thesoutheast of ahvaz, where some metal producing industries are active. the aim of this studywas to investigate and compare manganese (mn) and zinc (zn) accumulation in seven dominantherbaceous plants in this area. plant samples were collected randomly. associated soils weresampled from the same sites next t...

Chromosomal defects are relatively frequent in infertile men however, translocations between the Y chromosome and autosomes are rare and less than 40 cases of Y-autosome translocation have been reported. In particular, only three individuals has been described with a Y;21 translocation, up to now. We report on an additional case of an infertile man in whom a Y;21 translocation was associated wi...

Introduction: Intellectual disability or intellectual retardation is a condition in which total mental functioning is distinctively below average and there are disabilities in adaptive behaviors during growth. According to the definition of American Mental Disability Community in 1992 a person is considered intellectually disabled if he or she has an IQ (intelligence quotient) of less than 70...

the most significant complication of pregnancy is recurrent miscarriage. numerous factors have been described as associations with recurrent wastage such as: uterine abnormalities, immunological factors, endocrinologic imbalance and chromosomal defects. cytogenetic evaluation of couples with recurrent pregnancy losses is performed on the basis of g-banding technique only after other possible et...

Background: The human AML1 gene, located on chromosome 21, can be fused to the AML1- eight-twenty-one (ETO) oncoprotein on chromosome eight, resulting in a t(8;21)(q22;q22) translocation. Acute myeloid leukemia (AML) associated with this translocation is considered a distinct AML with a favorable prognosis. Due to the various incidences of the translocation, which is associated with geographic ...

The herpes simplex virus type 1 (HSV-1) tegument protein, VP22 has been reported to have the property of intercellular transport. The previous studies have shown that following expression of a fusion protein containing VP22 it spreads to every cell in a monolayer and concentrates in the nucleus. In spite of these reports, some studies have shown that VP22 trafficking and its nucleus accumulatio...