نتایج جستجو برای: transversion
تعداد نتایج: 1000 فیلتر نتایج به سال:
Evolutionary parsimony is an easy-to-use method of phylogenetic inference that is based on nucleic acid sequences and that does not require the assumption that evolutionary processes in the various sites on the molecule are identical. It does, however, require a parameter constraint, known as the “balanced transversion” assumption. We show that the accuracy of the procedure is fairly insensitiv...
Although several decades of study have revealed the ubiquity of variation of evolutionary rates among sites, reliable methods for studying rate variation were not developed until very recently. Early methods fit theoretical distributions to the numbers of changes at sites inferred by parsimony and substantially underestimate the rate variation. Recent analyses show that failure to account for r...
Nucleotide sequence polymorphism in a 641-bp novel major noncoding region of mitochondrial DNA (mtDNA-NC) of the Pacific oyster Crassostrea gigas was analysed for 29 cultured individuals within the Goseong population. A total of 30 variable sites were detected, and the relative frequency of nucleotide alteration was determined to be 4.68. Alterations were mostly single nucleotide substitutions....
An accurately inferred phylogeny is important to the study of molecular evolution. Factors affecting the accuracy of a phylogenetic tree can be traced to several sequential steps leading to the inference of the phylogeny. I examine here the features of the sequences in the alignment which impact phylogenetic (topological) accuracy rather than any source of error during the process of sequence a...
In the study of molecular evolution, it is important to know the number of nucleotide substitutions per site (d) between DNA sequences. There are many different methods for estimating this number (for reviews, see Nei 1987, chap. 5; Gojobori et al. 1990)) but all of them depend on some simplifying assumptions and do not always give reliable estimates. Two important factors that should be consid...
Background: Molecular marker based cancer diagnosis gaining more attention in the current genomics era. So, Hspb1 and Tp53 gene characterization and their mRNA expression might be helpful in diagnosis andprognosis ofcat mammary adenocarcinoma. It will also add informationin comparative cancer genetics and genomics. Objectives: Eight tumors of Siamese cats were analyzed to ascertain germ-line an...
A simple mathematical method is developed to estimate the number of nucleotide substitutions per site between two DNA sequences, by extending Kimura's (1980) two-parameter method to the case where a G+C-content bias exists. This method will be useful when there are strong transition-transversion and G+C-content biases, as in the case of Drosophila mitochondrial DNA.
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