OBJECTIVE To evaluate efficacy of trazodone hydrochloride as an adjunctive treatment for anxiety disorders as well as treatment protocol, dose range, concurrent drug use, adverse events, and therapeutic response in dogs unresponsive to other pharmacologic agents. DESIGN Retrospective case series. ANIMALS 56 dogs with anxiety disorders treated at a referral veterinary behavior clinic. PROC...

The present study was conducted with the aim of elucidating the possible role of nitric oxide (NO) in the neuroprotective effects of trazodone used to treat chronic fatigue syndrome (CFS) in mice. Male albino mice were forced to swim for a six minute session each day for 7 days and the immobility period was recorded every other day. Trazodone (5 mg/kg and 10 mg/kg) was administered each day 30 ...

The effects of trazodone on the cyclic GMP elevation elicited by N-methyl-D-aspartate in rat cerebellar slices were analyzed. Trazodone inhibited in a concentration-dependent manner (EC50 = 0.82 nM) the cyclic GMP response evoked by 0.1 microM N-methyl-D-aspartate. The inhibition was near complete at 10 nM trazodone. The effect of 10 nM trazodone was unaffected by 0.3 microM spiperone or rauwol...

Background: Although unapproved by the FDA for treating insomnia, trazodone is commonly prescribed in US partly due to lack of scheduling, hence it’s perceived as safer than z-drugs and benzodiazepines. This study investigated abuse/dependence potential safety risks. Methods: Cases involving or benzodiazepines (temazepam, triazolam, estazolam) frequently insomnia were identified from Adverse Ev...

Background: This study aimed to evaluate the efficacy of trazodone in the treatment of nocturnal enuresis in school age children. Methods: Nine patients (7 male and 2 female) with nocturnal enuresis, resistant to regular treatments, received trazodone (25 mg/day, for the first week and 50 mg/day for the second week). Results: Marked improvement was observed in one case, while partial improvemen...

A simple and specific method is presented for the capillary gas chromatographic determination of trazodone in postmortem blood and tissues. The drug and trimethobenzamide, which was used as an internal standard, were extracted with 1% isopropanol in n-butyl chloride. Chromatography was accomplished with a short (4-m) methyl silicone capillary column and hydrogen carrier gas. This combination of...

OBJECTIVE This study aimed to evaluate the effects of repeated treatments with the sedative antidepressants mirtazapine and trazodone on driving performance and cognitive function. METHODS Nineteen healthy men received continuous nocturnal doses of 15-mg mirtazapine , 25-mg trazodone, or placebo for 8 days in a double-blinded, three-way crossover trial. Subjects were asked to perform three dr...

Plasma containing trazodone or mianserin was extracted. The organic phase containing trazodone was evaporated and the residue was reconstituted in dilute acid. Mianserin was back-extracted from the organic phase with dilute acid. Both drugs were chromatographed on mu Bondapak C18 columns, with phosphate/acetonitrile as the mobile phase. Peak-height ratios of drug/internal standard were linearly...

A low arousal threshold is believed to predispose to breathing instability during sleep. We hypothesized that trazodone, a non-myorelaxant sleep promoting agent, would increase the effort-related arousal threshold in obstructive sleep apnea (OSA) patients. Nine OSA patients (age 49±9 yr AHI 52±32 events/h) were studied on two nights, one with trazodone 100mg and one with a placebo, in a double ...

Sleep disorders are a common and poorly treated disease state. This double blind, four arm placebo-controlled, randomized trial compared (1) low dose trazodone, (2) Sentra PM, a neurotransmitter based medical food, (3) the joint administration of trazodone and the medical food Sentra PM and (4) placebo. There were 111 subjects studied in 12 independent sites. Subjects underwent baseline screeni...