Recent success of companion diagnostics along with the increasing regulatory pressure for better identification of the target population has created an unprecedented incentive for drug discovery companies to invest in novel strategies for biomarker discovery. In parallel with the rapid advancement and clinical adoption of high-throughput technologies, a number of knowledge management and system...

BACKGROUND The purpose of this study was to evaluate the effects of benzalkonium (BAK)-free travoprost monotherapy administered for 3 years on intraocular pressure and visual field performance. METHODS The intraocular pressure of 76 patients with normal tension glaucoma was monitored every 1-3 months. A Humphrey visual field test was performed every 6 months after treatment and compared with ...

. cross-cultural understanding dates back to the discovery of the third world, its peoples, and its religions. along this, the place of studying other peoples came in view. demography and orientalism were two disciplines which first aimed at studying other peoples regardless of their beliefs. after some thirty years, emphasis was laid on their beliefs, too. today after disproof of the anticipat...

Some observers of drug development argue that the pace of pharmaceutical innovation is declining, but others deny that contention. This controversy may be due to different methods of defining and assessing innovation. We conducted a systematic review of the literature to develop a taxonomy of methods for measuring innovation in drug development. The 42 studies fell into four main categories: co...

This paper represents the rst eeort to apply direct-manipulation (VIS) techniques to spatial data exploration providing mechanisms for visually querying as well as browsing spatial data and for reviewing the visual results for trend discovery. We present a visual query language (SVIQUEL) which allows us to specify the relative spatial position (both topology and direction) between objects using...

background and objectives: there is a growing trend towards investigating natural products as sources of compounds with biological effects and many researches have been carried out in order to find effective medications against many diseases. cancer is no exception and studies focusing on evaluating the effects of different materials on dna, give valuable information in cancer researches and ca...

This paper represents the rst eeort to apply direct-manipulation (VIS) techniques to spatial data exploration providing mechanisms for visually querying as well as browsing spatial data and for reviewing the visual results for trend discovery. We present a visual query language (SVIQUEL) which allows us to specify the relative spatial position (both topology and direction) between objects using...

A large volume of concrete data may change over time in a database. It is important to catch the general trend of such changes and nd data evolution (changing) regularities in databases in many applications. Because of the large volume of data, data evolution regularity cannot be simply expressed by enumeration of actual data. Machine learning technology should be adopted to extract such regula...

Background and objectives: There is a growing trend towards investigating natural products as sources of compounds with biological effects and many researches have been carried out in order to find effective medications against many diseases. Cancer is no exception and studies focusing on evaluating the effects of different materials on DNA, give valuable information in cancer researches and ca...