Background/Aim The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bone regeneration is based on the use of osteoinductive autogenous grafts as wel...

Adipose-derived stem cells (ADSCs) are ideal seed cells for use in bone tissue engineering and they have many advantages over other stem cells. In this study, two kinds of calcium phosphate/collagen composite scaffolds were prepared and their effects on the proliferation and osteogenic differentiation of ADSCs were investigated. The hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) composite sca...

The purpose of this prospective controlled study was to compare healing quality following the implantation of ultraporous β-tricalcium phosphate, containing either expanded autologous mesenchymal stromal cells (trial group, 9 patients) or β-tricalcium phosphate alone (control group, 9 patients), into femoral defects during revision total hip arthroplasty. Both groups were assessed using the Har...

OBJECTIVES The purpose of the present study was to evaluate bone healing in rabbit critical-sized calvarial defects using two different synthetic scaffold materials, solid biodegradable bioactive glass and tricalcium phosphate granules alongside solid and particulated autogenous bone grafts. MATERIAL AND METHODS Bilateral full thickness critical-sized calvarial defects were created in 15 New ...

The multi-sized porous β-tricalcium phosphate scaffolds were fabricated by freeze drying followed by slurry coating using a multi-sized porous sponge as a template. Then, gelatin was dip coated on the multi-sized porous β-tricalcium phosphate scaffolds under vacuum. The mechanical and biological properties of the fabricated scaffolds were evaluated and compared to the uniformly sized porous sca...

Bioactive glass-coated hierarchical porous tricalcium phosphate ceramics were constructed as both bone scaffolds and drug delivery devices to treat S. aureus -infected defects.

background: recently, tissue engineering has developed approaches for repair and restoration of damaged skeletal system based on different scaffolds and cells. this study evaluated the ability of differentiated osteoblasts from adipose‑derived stem cells (adscs) seeded into hydroxyapatite/ tricalcium phosphate (ha‑tcp) to repair bone. methods: in this study, adscs of 6 canines were seeded in ha...

63 Introduction Bone defects attributed to serious periodontitis, trauma, and injury are commonly encountered in the fields of dentistry, craniofacial surgery, and orthopedics. Although autogenous bone grafting is still considered the gold standard for treatment, this process has several drawbacks, such as the requirement of a second surgery and the limited availability of collectable bone [1]....

INTRODUCTION Rehabilitation with implants in the upper maxilla often implies a challenge due to the shortage and quality of the remaining bone. Different kinds of grafts have been described in an endeavour to solve these problems. AIM The purpose of this study was to assess the osteoconduction potential of an autogenous bone and B-Tricalcium Phosphate mixture, in the treatment of atrophic upp...