BI-128.De Souza W 1984. Cell biology of Trypanosoma cruzi.Int Rev Cytol 86: 197-285. Engel JC, Doyle PS, Palmer J, Hsieh I, Bainton DF,McKerrow JH 1998. Cysteine protease inhibitorsalter Golgi complex ultrastructure and function in Trypanosoma cruzi. J Cell Sci 111: 597-606.Figueiredo RCBQ, Soares MJ 1996. Low temperatureinhibits the uptake of transferrin-gold complexes ...

African trypanosomes contain a membrane-bound enzyme capable of removing dimyristylglycerol from the membrane-attached form of the variable surface glycoprotein (mfVSG; Ferguson, M. A. J., K. Halder, and G. A. M. Cross, 1985, J. Biol Chem., 260:4963-4968). Although mfVSG phospholipase-C has been implicated in the removal of the VSG from the trypanosome surface (Cardoso de Almeida, M. L., and M....

Eine Struktur-Aktivitäts-Beziehung des Naturstoffs Leucinostatin A führte zu zwei hochpotenten Verbindungen gegen das Protozoon Trypanosoma brucei mit verminderter toxischer Wirkung in vitro und vivo. Diese bildeten keine Resistenzen bei langzeitiger subletaler Exposition ihr Wirkmechanismus liegt der Destabilisierung inneren Mitochondrienmembran.

Trypanosoma cruzi: Morphological and Microtubular Changes Related to Epimastigote Differentiation under Hyperosmotic Stress Alba Marina Gimenez1* and Estela E. Machado1 1Department of Molecular Biology, Faculty of Exact Sciences, Physical-Chemical and Natural Sciences, National University of Río Cuarto, Río Cuarto (X5800) Córdoba, Argentina SOJ Microbiology & Infectious Diseases Open Access Res...

The frequent reappearance of patent parasitemia, mainly Trypanosoma congolense, in cattle maintained under isometamidium prophylaxis in the Upper Volta indicated that drug-resistant forms might be appearing. To investigate this possibility, trypanosome stocks were isolated in mice, their isometamidium sensitivity estimated and compared to that of stocks isolated before drug use was widespread. ...

1. Some strains of Trypanosoma lewisi may, at times, produce rapidly fatal infections in a large percentage of the rats infected. 2. In such strains of Trypanosoma lewisi, a sufficient degree of pathogenicity may persist to warrant the designation of these strains as pathogenic. 3. The pathogenicity of a given strain of Trypanosoma lewisi is not constant, but is subject to marked and even sudde...

Trypanosoma cruzi affects millions of people worldwide. Clinical variability of Chagas disease can be due to the genetic variability of this parasite, requiring further genome studies. Here we report the genome sequence of the T. cruzi Dm28c clone (TcI), a strain related to the sylvatic cycle of the parasite.

Abstract Herein we characterize Trypanosoma cruzi infections from blood and CSF samples in a case series of people with HIV Chagas disease. We identify different infecting T. populations highlighting qPCR usefulness for disease reactivation diagnosis evaluation treatment response.

We propose a new model for the Stumpy Induction Factor-induced slender to stumpy transformation of Trypanosoma brucei gambiense cells in immunosuppressed mice. The model is a set of delay differential equations that describe the time-course of the infection. We fit the model, using a maximum-likelihood method, to previously published data on parasitaemia in four mice. The model is shown to be a...