background: reversal of tubal ligation is requested by some women for various reasons. the present study aims to determine the rate of pregnancy after tubal ligation reversal. case: in these case series, we reported fifteen women who requested tuboplasty after tubal ligation. in these cases reversal of tubal ligation was done in 15 women. pregnancy occurred in 4 women (26.6%). two term pregnanc...

the current study conducted a finite element (fe) and experimental investigation on tubular channel angular pressing as a noble severe plastic deformation technique for producing ultrafine grained and nanostructure tubular components. to examine the effects of the tcap process on the strain distribution and deformation behavior, fe simulations were employed. the fe results demonstrated that equ...

bile duct ligation (bdl) is shown to induce cholestasis-related liver function impairments as well as consequent cognitive dysfunctions (i.e. impaired learning and memory formation). this study investigates the effects of cholestasis (14, 21 and 28 days post bile duct ligation) on spatial and non-spatial novelty detection, using a non-associative task. male mice weighing 30-35 g were used. chol...

This study was designed to examine the pathogenesis of the excretory defect produced by bilateral ureteral obstruction in the rat. After release of obstruction of 24 hr duration glomerular filtration rate was reduced to 20% of normal. Free flow proximal tubular pressure was normal, excluding residual obstruction as a cause of depressed filtration, and indicating that an intrarenal hemodynamic a...

Maternal conditions affect the growth of the fetal kidney, which begins to secrete urine during late gestation (Bakala et al., 1985; Schaeverbeke & Cheignon, 1980). For example, during pregnancy, the maternal kidney undergoes various changes such as an increase in glomerular filtration rate (Baylis, 1994; Atherton & Pirie, 1981) and an alteration in tubular function (Dafnis & Sabatini, 1992). F...

A 56-year-old healthy patient underwent colonoscopy after a positive fecal occult blood test result. This examination showed diverticulosis of the left side of the colon and, at 20cm from the anal verge, a 6-mm sessile polyp in the neck of a diverticulum with intradiverticular extension (●" Fig.1a). Narrow-band imaging showed a large tubular pit pattern: Kudo type III-L (●" Fig.1b). Using a gas...

BACKGROUND Sepsis-associated acute kidney injury (SA-AKI) is an independent risk factor for death in patients with sepsis, but treatment for it is limited. To improve the diagnosis and treatment of SA-AKI, we must first understand its pathogenesis. Recently, interleukin (IL)-17A has been shown to be associated with the pathogenesis of acute kidney injury and sepsis, but its role in SA-AKI remai...

The effects of advanced glycation end products (AGE) in the form of glycated albumin (GA) on the proinflammatory phenotype of cultured renal proximal tubular epithelial cells (PTEC) and the therapeutic potential of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist were studied. Human PTEC were exposed to medium alone or supplemented with albumin or GA with or without pre...

In mammalian cardiac ventricular myocytes, Ca influx and release occur predominantly at t-tubules, ensuring synchronous Ca release throughout the cell. Heart failure is associated with disrupted t-tubule structure, but its effect on t-tubule function is less clear. We therefore investigated Ca influx and release at the t-tubules of ventricular myocytes isolated from rat hearts ~18weeks after co...

The effects of caerulin, a CCK receptor agonist, and proglumide, a receptor antagonist, on hyperalgesia induced by sciatic nerve ligation, was studied in mice. Tolerance to the morphine response was obtained 3,7, 14,21 and 28 days after unilateral sciatic nerve ligation. Maximum hyperalgesia was found 14 days after nerve ligation. Caerulin increased morphine antinociception in nerve-ligated ani...