INTRODUCTION Fibroblast growth factor 23 (FGF23) is secreted from bone and suppresses the absorption of phosphorus in renal proximal tubule and in intestinal tract. Therefore, the increase of serum FGF23 levels leads to hypophosphatemic situations. Tumor-induced osteomalacia is often induced by various tumors, but it is often difficult to identify the localization of tumor, because most of the ...

Since phosphate is indispensable for skeletal mineralization, chronic hypophosphatemia causes rickets and osteomalacia. Fibroblast growth factor 23 (FGF23), which mainly produced by osteocytes in bone, functions as the central regulator of metabolism increasing renal excretion suppressing production 1,25-dihydroxyvitamin D. The excessive action FGF23 results hypophosphatemic diseases, include a...

Tumor-induced osteomalacia is a rare acquired metabolic bone disorder characterized by isolated renal phosphate wasting due to abnormal tumor production of fibroblast growth factor 23. We report the case of a 59 year old woman referred to our department with a long history of progressive diffuse muscle weakness and pain, generalized bone pains and multiple insufficiency fractures of heels, ankl...

Tumor-induced osteomalacia (TIO) is a rare but potentially curable disease. It is caused by excessive renal clearance ofphosphate induced by a substance secreted from the tumor Here, the authors report a Thai patient who presented with multiple pathologic fractures, low serum phosphorus, and low tubular maximum reabsorption of phosphorus/glomerular filtration rate (TmPO4/GFR). The clinical, bio...

Tumor-induced osteomalacia (TIO), also known as oncogenic osteomalacia, is a rare acquired paraneoplastic disease, which challenging to diagnose and treat. TIO characterized by hypophosphatemia resulting from excess levels of tumor-secreted fibroblast growth factor 23 (FGF23), one the key physiological regulators phosphate metabolism. Elevated FGF23 results in renal wasting compromised vitamin ...

Tumor-induced osteomalacia (TIO) is a rarely encountered paraneoplastic syndrome caused by small, usually benign tumor of mesenchymal origin. It can present with severe hypophosphatemia and osteomalacia, in adulthood, but also adolescence. The rarity these tumors often leads to late or missed diagnosis. Here we case TIO diagnosis for many years, which as result, presented multiple fractures. A ...

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic disorder in which a neoplasm causes systemic bone demineralization. Most cases are benign, but malignant neoplasms have been reported. The prognosis is good if diagnosis is made early and treatment is adequate. We present the case of a previously healthy 40-year-old man who presented with low back pain for the previous year. The initial ...