Hospital Physician September 2008 25 T umor lysis syndrome (TLS) is a collection of metabolic abnormalities that occur as a result of the release of intracellular contents following lysis of malignant cells, typically after initiation of chemotherapy. The features of TLS include hyperphosphatemia, hyperuricemia, hypocalcemia, hyperkalemia, and acute kidney injury. These features are observed wh...

Tumor lysis syndrome (TLS) is a known complication of malignancy and its treatment. The incidence varies on malignancy type, but is most common with hematologic neoplasms during cytotoxic treatment. Spontaneous TLS is thought to be rare. This case study is of a 62-year-old female admitted with multisystem organ failure, with subsequent diagnosis of aggressive B cell lymphoma. On admission, labo...

From the Department of Oncology and International Outreach Program, St. Jude Children’s Research Hospital (S.C.H., C.-H.P.), and the Department of Pediatrics, University of Tennessee Health Sciences Center, College of Medicine (S.C.H., D.P.J., C.-H.P.) — both in Memphis. Address reprint requests to Dr. Howard at St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Barry-Longinotti Bld...

Preoperative splenic artery embolization for massive splenomegaly has been shown to reduce intraoperative hemorrhage during splenectomy. We describe a case of tumor lysis syndrome after proximal splenic artery embolization in a patient with advanced mantle cell lymphoma and splenic involvement. The patient presented initially with hyperkalemia two days after embolization that worsened during sp...

background: burkitt’s lymphoma is a high grade b-cell neoplasm, which is a kind of small non-cleaved cell lymphoma . it is presumably the fastest growing human malignancy, and the patients are prone to develop tumor-lysis syndrome. here we present findings on our patients with burkitt lymphoma . materials and methods: this descriptive retrospective study included 46 children with abdominal burk...

BACKGROUND This case report describes a spontaneous tumor lysis syndrome due to a rare solid tumor. CASE PRESENTATION A 65-year-old white woman had tumor lysis syndrome, which represent a dangerous oncological emergency. This syndrome occurs usually with a hematological tumor, but in this case our patient had a solid tumor, which was a rare extraskeletal osteosarcoma, localized in her pelvic ...