This paper proposes an approach to improve atlas-to-image registration accuracy with large pathologies. Instead of directly registering an atlas to a pathological image, the method learns a mapping from the pathological image to a quasi-normal image, for which more accurate registration is possible. Specifically, the method uses a deep variational convolutional encoder-decoder network to learn ...

It is of great importance to classify the gene expression data into different classes. In this paper, followed the assumption that the gene expression data of tumor may be sampled from the data with a probability distribution on a sub-manifold of ambient space, an efficient feature extraction method named as Constrained Maximum Variance Mapping (CMVM), is presented for tumor classification. The...

Methods that allow robust imaging of specific molecular targets and biological processes in vivo should have widespread applications in biology and clinical medicine. Here we use a quantitative, three-dimensional fluorescence-mediated tomographic technique (FMT) that enables rapid measurements of fluorochrome-based affinity tags in live xenograft models. We validate the method by showing its se...

Functional Cortical Mapping Using Subdural Grid Electrodes in Patients with Low-Grade Gliomas Presenting with Seizure P low-grade brain tumors in eloquent cortex are challenging lesions to resect. The margin between infiltrating tumor and normal white matter is often indistinct, and their removal risks significant postoperative disability. Several mapping techniques have been developed to limit...

Objectives B cell-mediated immunity can be associated with favorable clinical outcomes in cancer patients. However, the mechanism and features of anti-tumor immune responses are not well understood. In particular, how cells expressing tumor-specific antibodies distributed (in tumor vs. circulation) has been defined. Methods We performed an in-depth analysis cell antibody repertoires derived fro...

conclusions pc-rplnd is one the major operations in the field of urology, which is associated with significant adjunctive surgeries. in appropriate cases, pc-rplnd was associated with good cancer specific survival in tertiary oncology center. results twenty-one patients underwent bilateral pc-rplnd. mean age was 26.3 years (ranged 16 - 47). mean size of retroperitoneal mass after chemotherapy w...

Introduction. Aggressive surgical resection constitutes the optimal treatment for intracranial gliomas. However, the proximity of a tumor to eloquent areas requires exact knowledge of its anatomic relationships to functional cortex. The purpose of our study was to evaluate fMRI's accuracy by comparing it to intraoperative cortical stimulation (DCS) mapping. Material and Methods. Eighty-seven pa...